Biophysicist Job Description Sample
Temporary Research Scientist I
Temporary contract, 12 months
We seek a highly motivated and innovative scientist with a passion to apply biophysical techniques to drug discovery. The ideal candidate will have a proven track record in biochemical and biophysical research including protein purification and expression, development of functional assays and structural studies on integral membrane protein. The Research Scientist will work within a team of biochemists, biophysicists and structural biologists in support of determining target mechanism of action and ligand engagement.
Expression and purification of integral membrane proteins for use in biophysical and functional assays
Participate in experimental design and independently conducts experiments
Optimize and carry out biophysical protein-ligand measurements
Maintain clear records of experimental work and be able to organize, report and communicate their results
PhD in Structural Biology, Biochemistry, Biophysics or relevant field with 0-2 years post-degree experience
Experience in protein expression from multiple organisms (mammalian, insect, bacterial, etc.)
Track record of protein purification of targets including membrane proteins
Previous use of manual and automated chromatography systems
Use of biochemical techniques (e.g. Western blot, SDS-PAGE, etc.)
Familiarity with biophysical techniques an asset (e.g. SPR, MST, ITC, etc.)
Self-motivation, organization, effective communication and presentation skills
Ability to navigate a fast-paced work environment
A desire to be part of a highly innovative company aimed at transforming the lives of people with serious diseases, their families and society
Senior Scientist, X-Ray Crystallography
Janssen Research &Development, L.L.C., a division of Johnson & Johnson's Family of Companiesis recruiting for a Senior Scientist, X-rayCrystallography, located in Spring House, PA.
At the Janssen Pharmaceutical Companies of Johnson & Johnson, what mattersmost is helping people live full and healthy lives. We focus on treating,curing and preventing some of the most devastating and complex diseases of ourtime. And we pursue the most promising science, wherever it might befound.
Janssen Research & Development, LLC discovers and develops innovativemedical solutions to address important unmet medical needs in oncology,immunology, neuroscience, infectious diseases and vaccines, and cardiovascularand metabolic diseases. Please visit http://www.janssenrnd.com/ for moreinformation.
The Lead Discovery group is a critical part of the Discovery Sciences (DS)organization in Janssen R&D and is committed to the delivery of highquality chemical starting points needed for the generation of small moleculeclinical compounds in all five Janssen Therapeutic Area (TA) discovery teams.This mission requires deep scientific expertise in a number of disciplinesincluding chemistry, cellular and molecular pharmacology, enzymology, HTS, andstructural biology coupled with an ability to work collaboratively withinternal and external partners. Building on a strong legacy of success, we arecurrently seeking an outstanding individual to join our team as Senior Scientist,X-ray Crystallography.
The Senior Scientist will:
Beresponsible for crystallization of protein-small molecule complexes anddetermination of high-resolution structures by x-ray crystallography
Work closely with proteinscientists, biophysicists and protein NMR scientists as part of an integratedstructural biology effort
Bring in-house innovative structuralbiology technologies
Be a member of drugdiscovery teams, working closely with computational and medicinal chemists onstructure-based drug design approaches for small molecule agent optimization
Contribute tomultidisciplinary Fragment-Based Lead Discovery (FBLD) efforts
Contribute to increase thestructural biology scientific expertise of the group by publishing high-impactresearch papers and establishing academic collaborations
Mentor lab scientists andcontribute to the strategic planning of the Structural Biology group
Ph.D.or equivalent with postdoctoral experience in structural biology (x-raycrystallography or protein NMR) or a related field is required
Deepscientific expertise in structural biology is required
Strongexperience in both protein crystallization and high-resolution structuredetermination is required
Aminimum of 5 years of drug discovery experience with a record of importantcontributions to programs is required
Experiencein Structure Based Drug Design (SBDD) utilizing x-ray crystallography isrequired
Strongrecord of external publications and presentations is required
Outstandingwritten and oral presentation skills is required
Experiencein scientific programming (Unix shells, Python, Perl), and ability to work withthe latest relevant software packages and in a mixed Linux/Windows computationalenvironment is preferred
Researchexperience in biophysics, biochemistry, molecular pharmacology, and proteinsciences is preferred
Researchexperience in cryo-electron microscopy (Cryo-EM) and other novel structuralbiology technologies is preferred
Linemanagement experience is preferred
Expertise in one or more of the following therapeutic areas: Oncology,Inflammation, Neuroscience, Cardiovascular, and Infectious Diseases is preferred
Johnson & Johnson is an AffirmativeAction and Equal Opportunity Employer. All qualified applicants will receiveconsideration for employment without regard to race, color, religion, sex,sexual orientation, gender identity, age, national origin, or protected veteranstatus and will not be discriminated against on the basis of disability.
United States-Pennsylvania-Spring House-1400�McKean�Road
Janssen Research & Development, LLC. (6084)
Scientist II, Biophysics - San Diego, CA
Are you looking for a patient-focused company that will inspire you and support your career? If so, be empowered to take charge of your future at Takeda. Join us as an Scientist II, Biophysics in our San Diego office.
Here, everyone matters and you will be a vital contributor to our inspiring, bold mission. As a Scientist II, Biophysics on the Structured Biology and Biophysics team, you will be empowered to proactively identify opportunities for ITC, SPR and other technologies to investigate soluble and membrane proteins.
The Scientist II, Biophysics independently implements biophysics strategies to study protein interactions with small molecule ligands and biomolecules. Scientist IIis well-versed in the use of SPR and other biophysics approaches for hit identification, validation, and lead optimization. Associate Scientist has a track record of determining thermodynamic and kinetic parameters governing protein binding and has a deep understanding of membrane proteins and biologics.
The Scientist II, Biophysics will work closely with structural biologists, chemists, and biologists in preclinical research projects and will be responsible for providing effective and innovative solutions to address program-specific needs and challenges. Scientist II, Biophysics also leads external collaborators with private and academic institutions to outsource research and provide access to skills, resources and capabilities that supplement Takeda's.
Manage the design, development, and implementation of experiments to support drug discovery projects and characterizes small molecule and antibody interactions with membrane proteins.
Proactively identify opportunities for SPR and other technologies to investigate soluble and membrane proteins
Work closely with other biophysicists in the team to develop integrative approaches to address specific challenges and bottlenecks.
Lead the identification and utilization of current and emerging biophysical technologies – for use internally or accessed via external partners – that will favorably impact projects.
Identify opportunities to collaborate with partners (academic, biotech, and CRO) to enhance in-house capabilities. Leads and manages external collaborations effectively.
Work closely with the Structural Biology and Biophysics Group to develop integrative approaches to address specific challenges and bottlenecks.
Participate on cross-functional teams and provides technical leadership in the areas of biophysics.
Effectively present data to other scientific staff and cross-functional project teams; may present data/posters to external research or scientific community.
EDUCATION, EXPERIENCE, KNOWLEDGE AND SKILLS:
Ph.D.in Biochemistry, Biophysics, or related discipline with 2+ relevant years in a research and/or development environment, or MS degree with at least 8+ years of biophysics experience, or BS degree with at least 10+ years of biophysics experience, and a demonstrated working knowledge of biophysics scientific principles, or equivalent.
Demonstrated experience with biophysical techniques including, TSA, SPR, ITC, DLS, and fluorescence spectroscopy.
Demonstrates fundamental understanding of drug discovery within one or more areas.
Experience in the study of membrane proteins and antibody-antigen interactions as well as a good understanding of other biophysical techniques like MS and NMR.
Strong track record for studying protein interactions and macromolecular complexes as evidenced by quality and quantity of publications/presentations/inventions.
Familiar with other structural biology methods like X-ray crystallography, NMR spectroscopy and electron microscopy.
Experience with preparation of high-quality protein samples for biophysics studies.
Good team player with positive attitude and strong collaboration skills including the ability to work individually as well as part of an effective team.
Highly motivated and flexible with the ability to work in a fast-paced environment. Ability to provide novel creative solutions to challenging problems. Desire to learn and tackle new challenges and initiatives.
Detail oriented and with very high scientific standards.
Demonstrated interest in applying biophysics strategies to fragment based drug discovery.\
Proven track record of scientific contributions in life science as evidenced by quality and quantity of publications/presentations/inventions and/or products and clinical candidates
Excellent verbal and written communication skills.
Ability to work in fast-paced, collaborative, team-oriented environment.
Ability to provide novel creative solutions to challenging problems.
Desire to learn and tackle new challenges and initiatives.
Professionally represents Takeda in collaborations, partnership discussions, and external relationships and conferences.
Use hands on a regular basis to handle small laboratory equipment, including multi-channel pipettors, for liquid transfers to and from 96- and 384-well plastic assay plates.
Able to lift or move up to 10 pounds on a regular basis in the course of daily work.
Exposure to hazardous/toxic/dangerous chemicals.
- Less than or equal to 5% travel, consisting of one to two relevant scientific meetings and/or trips to meet with collaborators and CROs
WHAT TAKEDA CAN OFFER YOU:
401(k) with company match and Annual Retirement Contribution Plan
Company match of charitable contributions
Health & Wellness programs including onsite flu shots and health screenings
Generous time off for vacation and the option to purchase additional vacation days
Community Outreach Programs
Empowering Our People to Shine
Learn more at takedajobs.com.
Takeda is an EEO employer of minorities, women, disabled, protected veterans, and considers qualified applicants with criminal histories in accordance with applicable laws. For more information, visit http://www.takeda.us/careers/EEO_Policy_Statement.aspx
No Phone Calls or Recruiters Please.
San Diego, CA
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