Cell Coverer Job Description Sample
Cell Manufacturing Associate II - CAR T Cell Manufacturing
About City of Hope
City of Hope, an innovative biomedical research, treatment and educational institution with over 6000 employees, is dedicated to the prevention and cure of cancer and other life-threatening diseases and guided by a compassionate, patient-centered philosophy.
Founded in 1913 and headquartered in Duarte, California, City of Hope is a remarkable non-profit institution, where compassion and advanced care go hand-in-hand with excellence in clinical and scientific research. City of Hope is a National Cancer Institute designated Comprehensive Cancer Center and a founding member of the National Comprehensive Cancer Network, an alliance of the nation's leading cancer centers that develops and institutes standards of care for cancer treatment.
Responsible for manufacturing and testing of biological products including, but not limited to, genetic T cell modification to express chimeric antigen receptors for cancer treatment under limited supervision. Participate in the efforts in achieving compliance with all Federal and State accrediting agency requirements in the manufacturing and testing of biopharmaceutical and genetic products manufactured in the Center for Biomedicine and Genetics (CBG) or Cellular Therapies Production Center (CTPC). Perform manufacturing activities, process development tasks, and assay development tasks as directed by supervisor. Perform general laboratory activities assigned by supervisor. Provide qualification and validation support for manufacturing processes and quality assurance procedures that are essential to the cGMP production of biomedical products. Perform all cGMP related activities strictly according to SOP with accurate documentation. Cooperate with Quality Assurance group to ensure the quality of product and cGMP compliance. Required to wear pager, or other communication devices, and respond to emergency calls.
Key Responsibilities include:
Manufacture and test biological products following established SOP under limited supervision.
Cooperate with Quality Assurance group to ensure the quality of product and cGMP compliance.
Participate in the efforts in achieving compliance with all Federal and State accrediting agency requirements.
Assist in development/adaptation of new manufacturing procedures and analytical methodology.
Perform general laboratory activities.
Wear pager, or other communication devices, and respond to emergency calls.
Perform manufacturing activities and release testing following established SOP. Participate in the efforts to develop and adapt new procedures for manufacturing and testing when necessary. Complete all documents in compliance to cGMP.
Assist in creating, reviewing and revising Standard Operating Procedures as necessary.
Assist in internal inspections and audits to ensure compliance with Federal Drug Administration (FDA) regulations and City of Hope and CBG/CTPC procedure requirements.
Participate in general laboratory activities as assigned by supervisor.
Complete and maintain all training required to perform assigned tasks.
Cooperate with other performance improvement and compliance activities within the department and in the institution.
Maintains current knowledge of manufacturing/analytical techniques and industry practices.
Basic education, experience and skills required for consideration:
Minimum education:BS degree in biological science or related field.
Experience may substitute for minimum education requirements.
Minimum experience:3-5 years related experience with B.S. degree, or 0-4 year with M.S. degree.
Required courses/training:Basic biology and chemistry.
Preferred education experience and skills:
Preferred education:B.S. or M.S. in biological science, or related field.
Preferred Courses/Training:Basic Biology (Molecular and Cellular), Chemistry (Inorganic, Organic and Biochemistry), Virology, Immunology, Cancer biology.
Preferred Experience:Biotechnology, Pharmaceutical industry experience.
Have previous experience with cell therapy products; Excellent aseptic techniques;
Strict adherence to SOPs and cGMP regualtions, the ability to accurately complete documentation associated with clinical manufacturing; Demonstrate trouble shooting and problem solving skills; Foster and promote a positive image and professional appearance; Organized and efficient; Excellent writing and computer skills;
Able to correctly use technical terms and abbreviations; Comfortable with a fast-paced environment; Able to adjust workload based upon changing priorities.
Good written and oral communication skills, team player, self-motivated excellent personal hygiene; Practice good judgment in all professional activities; Ability to analyze data and compose reports; Ability to develop and update policies and procedures; Ability to set and model professional work standards;
Software:Microsoft Office, Access, Excel, Windows NT, Word and miscellaneous device control software.
Machines/Equipment:Dispensing pumps, heat sealers, welder, rotator, CliniMACS and/or and/or Prodigy and/or any cell separation equipment, magnetic separators, cell counting equipment, cell washers, flow cytometer, centrifuges, microscopes, biosafety cabinet and incubator.
City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.
Editor-In-Chief Cell Genomes
We are looking for a dynamic individual with editorial and publishing expertise to launch and lead a new Cell Press journal covering basic and applied research related to the biology of genomes.
As the Editor-in-Chief of this new journal related to genome research, you assume overall responsibility for setting the journal's scientific scope at launch and determining its editorial direction after launch. You will build and lead an editorial team at the journal. You will also be responsible for ensuring the quality and quantity of the research articles published in the journal. You will be expected to travel to attend conferences, seminars, and scientific meetings and to build a broad network of domestic and international contacts. The Editor-in-Chief will also need to develop and foster partnerships members of the production, marketing, press and advertising teams, as well as with other editorial teams at Cell Press, and to contribute to the overall publishing strategy of Cell Press. The Editor-in-Chief will also be expected to establish a healthy working relationship with the key stakeholders at the American Journal for Human Genetics (AJHG).
This is an exciting opportunity to launch, shape and lead a new journal in the genome sciences area as part of the vibrant and growing Cell Press journal portfolio.
The position is based in Cambridge, MA, where the Cell Press offices are located, and will report to a Publishing Director at Cell Press.
Your responsibilities will include:
- developing the overall scope and editorial direction of the new journal
- hiring and managing a team of scientific editors
- building the editorial board
- working with marketing to define the value proposition and brand identity
- managing day-to-day operations at the new journal
- recruiting exciting papers within the scope of the journal
- collaborating on defining production workflows, marketing, social media and website after launch
The qualified candidate is expected to have:
- a Ph.D. in any area of biology
- 5+ years of editorial experience
- broad interest across the full spectrum of genome and genetics research
- established network with the genome and genetics research community
- project and/or people management skills
- strong organizational skills
- strong written and oral communication skills
- interest in engaging with the scientific community
- previous management experience is beneficial but not required
We welcome you to a truly global, dynamic and challenging environment offering great opportunities to develop yourself. Our benefits package includes:
Competitive salary commensurate with experience
Excellent medical, dental and 401K benefits
Opportunity to advance within the organization among many divisions (worldwide)
To apply, please submit your resume and a cover letter outlining your motivations for being interested in the job. We will consider applications on a rolling basis until August 20, 2019.
An assessment or business case could be part of our selection procedure. A pre-employment screening will be part of our recruitment procedure.
Elsevier is a global information analytics business that helps institutions and professionals progress science, advance healthcare and improve performance for the benefit of humanity. We help researchers make new discoveries, collaborate with their colleagues, and give them the knowledge they need to find funding. We help governments and universities evaluate and improve their research strategies. We help doctors save lives, providing insight for physicians to find the right clinical answers, and we support nurses and other healthcare professionals throughout their careers.
Elsevier provides digital solutions and tools in the areas of strategic research management, R&D performance, clinical decision support, and professional education; including ScienceDirect, Scopus, SciVal, ClinicalKey and Sherpath. Elsevier publishes over 2,500 digitized journals, including The Lancet and Cell, more than 35,000 e-book titles and many iconic reference works, including Gray's Anatomy. Elsevier is part of RELX Group, a global provider of information and analytics for professionals and business customers across industries.
Elsevier employs over 7,000 people in more than 70 offices worldwide. We are an employer of choice, attracting and developing talented and creative people who thrive in a challenging and fast-paced environment. We offer an excellent compensation and benefits package as well as a real opportunity for career growth in a growing organization. Elsevier is an equal opportunity employer: qualified applicants are considered for and treated during employment without regard to race, color, creed, religion, sex, national origin, citizenship status, disability status, protected veteran status, age, marital status, sexual orientation, gender identity, genetic information, or any other characteristic protected by law. If a qualified individual with a disability or disabled veteran needs a reasonable accommodation to use or access our online system, that individual should please contact 1.877.734.1938 or email@example.com.
Faculty Position- Stem Cell Biology Program
Childrens Research Institute (CRI) at the University of Texas Southwestern Medical Center in Dallas, TX seeks applications for a tenure-track faculty position in the area of stem cell biology. Outstanding investigators at any rank will be considered.
Appointment rank will be commensurate with academic accomplishments and experience. Candidates must have a Ph.D., M.D. or equivalent degrees and the ability to direct an independently-funded research program exploring any aspect of stem cell biology.
UT Southwestern Medical Center has a long and distinguished history of excellence in disease-related basic science research. CRI is recruiting outstanding individuals dedicated to solving fundamental problems in biology and disease.
CRI is a dynamic and highly collaborative scientific environment. Major areas of focus within CRI will include stem cell biology, cancer biology, and metabolism.
Please submit a CV, a 2-page summary of past accomplishments and research plans, and ask three references to submit letters by November 1, 2018 to CRIApplicants@utsouthwestern.edu.
UT Southwestern is an Affirmative Action/Equal Opportunity Employer. Women, minorities, veterans, and individuals with disabilities are encouraged to apply.
Cell Leader (Fabrication)
Support the fabrication activities of the sheet metal, anodize and paint shop secondary operations.
Work under the direction of the Value Stream Leader/Business Unit Manager, with little or no supervision.
Update Production charts (Visual management tools) and report production activities, team goals and countermeasures to management during daily management meetings.
Implement training, new procedures, and oversee manufacturing operations in the related area.
Work closely with production planners; oversee stock room activities and transactions, and work order close outs.
Monitor shortages, and order non inventory items as required.
Provide day-to-day leadership to employees while working as a member of the team in the area.
Communicate key messages to the team members, and lead the team in daily stand up / shift start up meetings.
Schedule work / assignments required to meet company goals and customer required deliveries.
Work closely with the Business Unit Manager/Value Stream Leader to resolve all problems and conflicts
Ensure that all paperwork is completed properly in related area.
Review and approve daily time and attendance and approve time off requests.
Responsible for yearly employee performance reviews and employee corrective actions .
Manage and schedule daily department overtime as needed to meet OTD schedule.
High School Diploma or equivalent (i.e. GED)
Basic math, reading and writing skills
Ability to effectively communicate, understand and follow all verbal and written instructions
Must be proficient in computer skills to access production information as required
Must have experience in MS Excel and MS Word
SAP experience preferred.
Minimum of 3 years of work experience in a fabrication environment is required
Experience working with sheet metal machinery, heat treating and surface finishing processes and applications.
Prior supervisory experience is required.
Work overtime as assigned.
Required Lifting Weight: 30 lbs. Lifting Frequency: Daily
Bend, lift, sit and/or stand for long periods of time
Identify cost savings and help implement changes.
Maintain and oversee all point of use/floor inventory in related area.
Maintain a clean, neat, and healthy work environment.
Work safely following all safety procedures.
Perform preventive maintenance as required.
Must be willing to work overtime as required including weekends to meet company goals.
Perform other duties as required.
This position requires access to export-controlled commodities, technical data, technology, software, and services. U.S. citizenship, U.S. legal permanent resident status, protected person status, or U.S. Government export authorization is required. Any offer of employment is contingent upon Pall obtaining the necessary employment visa and export authorization, including, if required, an export license from the applicable U.S. government agency.
Diversity & Inclusion
At Danaher, we are dedicated to building and sustaining a truly diverse and inclusive culture. These are not just words on a page—Diversity and Inclusion is a top priority for the company, and it ties deeply to each of our core values. Danaher Corporation and all Danaher Companies are equal opportunity employers that evaluate applicants without regard to race, color, national origin, religion, sex, age, marital status, disability, veteran status, sexual orientation, gender identity, or other characteristics protected by law.
Cell Site Engineer
What you'll be doing...
Join Verizon as we continue to expand our industry-leading network to improve the ways people, businesses, and things connect. Verizon is positioned to lead in the emergence of new technologies like our best-in-class 5G network and the Internet of Things (IoT) to impact a wide variety of industries including healthcare, education, manufacturing, public safety, government, and many others. We are in the midst of historic breakthroughs in connectivity and mobility to blend the physical and the digital through cutting-edge technologies such as virtual reality, augmented reality, artificial intelligence, autonomous vehicles, nanotechnologies, 3D printing, wearables, and advanced robotics. As part of this team, you will play a critical role in our network transformation through building a unified network across all lines of business and maintaining the technology that keeps millions of our customers connected.
Our people are our most valuable assets, but our equipment is pretty important too. As a Cell Site Engineer, you'll be out in the field keeping our facilities and equipment in top form by maintaining several locations in your assigned area. You'll be upgrading and maintaining cell sites and installations, performing regular maintenance, keeping inventories and completing audits. You'll also be analyzing our network coverage and finding ways to make it even better.
Performing optimization, troubleshooting, and maintenance of base station equipment, RF transmitters, and Fiber network.
Testing fiber network and integrate network hardware to bring new products on-air and enhance customer experience.
Analyzing network coverage to find gaps, making recommendations to improve coverage, and helping to implement those recommendations.
Conducting routine, preventative maintenance on assigned cell sites to identify potential issues during general site inspections.
Complying with company- and industry-wide standard directives to maintain network performance and enhance efficiency.
What we're looking for...
You're tech savvy and well-versed in all things telecommunications. Working independently suits you well. You're also thorough, vigilant, and on top of the details—someone people count on to solve problems and to keep them from happening in the first place.
You'll need to have:
Associate's degree or two or more years of work experience.
Three or more years of relevant work experience.
Valid driver's license.
Even better if you have:
A technical degree in Electronics or Telecommunications.
Experience troubleshooting antenna systems from transmitter to antenna using tools like a spectrum analyzer.
Expertise in PIM/VSWR/MIMO/RET including knowledge of fiber and LTE remote radio heads.
Electronics training in telecommunications, two-way radio, paging, or microwave radio.
Training in data communications, digital communications, operating systems and applications, computer support, scripting, project management, or power.
Experience with Lucent, Motorola, Nokia, Samsung, or Ericsson, base station equipment with LTE or CDMA technology.
Telecom experience such as T1, DACS, or OMP.
Experience with dark and lit fiber testing using equipment such as OTDR, fiberscope,
Computer support experience, including troubleshooting PC hardware and configurations.
Power experience such as Galaxy, Lorain, or DC distribution systems.
Willingness to travel occasionally as needed.
When you join Verizon...
You'll be doing work that matters alongside other talented people, transforming the way people, businesses and things connect with each other. Beyond powering America's fastest and most reliable network, we're leading the way in broadband, cloud and security solutions, Internet of Things and innovating in areas such as, video entertainment. Of course, we will offer you great pay and benefits, but we're about more than that. Verizon is a place where you can craft your own path to greatness. Whether you think in code, words, pictures or numbers, find your future at Verizon.
Equal Employment Opportunity
We're proud to be an equal opportunity employer- and celebrate our employees' differences,including race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, and Veteran status. Different makes us better.
Integrator- Cell Analysis
Role Summary:Performs diverse and complex assignments in support of GEHC product development and manufacturing. Assignments may include, but are not limited to: fabrication and assembly of fixtures and equipment, set up and running of data acquisition equipment for tests, carrying out experiments, reporting/documenting results of tests and measures, lead compliance and quality activities and train other team members.
• Integrate and test complex systems to determine for correct operation and compliance to performance specifications.
Test complex production assemblies and sub-assemblies for correct operation and compliance to performance specifications.
Performs quality control visual inspections or functional operation of material or product before and after integration.
Utilizes advanced problem solving and trouble shooting skills to check electrical and mechanical performance of integrated systems to ensure compliance with product quality standards and make necessary adjustments when required.
Working to standard operating procedures and instructions from Supervisor, Engineers, and Quality Assurance in order to meet established specifications and time standards.
Must comply with the GEHC Quality Manual, Quality Management System, Quality Management Policy, Quality Goals, and applicable laws and regulations as they apply to the job.
Completes all administrative functions and records proper documentation for integration of products.
Able to conduct job training and assist other employees and departments as required.
Must comply with EHS regulations and policies.
• Technical Associates Degree with 3 to 5 years of technical manufacturing experience, or equivalent Cell Analysis manufacturing experience.
Good written and oral communication skills in English.
Ability to read and interpret complex assembly drawings, wiring diagrams, and complex standard work instructions.
Uses fixtures, hand tools, special tools, gauges, and assembly tools to assemble, modify, measure, adjust test, or repair products.
Proficient computer skills and knowledge of document control systems.
Self-sufficient worker demonstrating the ability to work independently and/or in a team setting.
Able to learn and work with engineers in developing new products
Ability to frequently sit, stand, walk, reach within hands and arm's length, stoop kneel, and crouch
Ability to regularly lift/and or move up to 10 pounds, occasionally lift and/or move up to 25 pounds.
Will be required to wear personal protective equipment.
Occasional overtime required.
Desired Characteristics:• Experience in medical device assembly.
Familiarity with 5S standards and the ability to apply and maintain the standards on the shop floor.
Experience with optical systems.
Experience working in a Lean or Six Sigma manufacturing environment.
About Us:GE (NYSE:GE) drives the world forward by tackling its biggest challenges. By combining world-class engineering with software and analytics, GE helps the world work more efficiently, reliably, and safely. GE people are global, diverse and dedicated, operating with the highest integrity and passion to fulfill GE's mission and deliver for our customers. www.ge.com
GE offers a great work environment, professional development, challenging careers, and competitive compensation. GE is an Equal Opportunity Employer. Employment decisions are made without regard to race, color, religion, national or ethnic origin, gender (including pregnancy), sexual orientation, gender identity or expression, age, disability, veteran status or any other characteristics protected by law.
GE will only employ those who are legally authorized to work in the United States for this opening. Any offer of employment is conditioned upon the successful completion of a drug screen (as applicable).Additional Locations:United States;Washington;Issaquah;
Registered Nurse RN Sickle Cell
At Banner Health, we understand that talented health care professionals appreciate having options. We are proud to offer our more than 50,000 employees many career and lifestyle choices throughout our network of facilities.
The people of Banner Health are focused on delivering excellent care to our patients. In return, we are committed to excellence in personal development for all our employees.
Our Adult Sickle Cell Clinic provides hydration and pain management to affected individuals suffering from the chronic illness of sickle cell anemia. Additional treatments are available to this population in an as-needed basis decreasing the need for emergency care management of their disease and comorbidities.
This is a full time, benefit eligible position. Hours are 5:45am-6:15pm, Mon-Fri.
Your pay and benefits (Total Rewards) are important components of your Journey at Banner Health. Banner Health offers a variety of benefit plans to help you and your family. We provide health and financial security options so you can focus on being the best at what you do and enjoying your life.
If you are a New Graduate Nurse with less than 12 months of experience, please apply to our New Nurse Experience openings.
- University Medical Center Phoenix
University Medical Center Phoenix is a nationally recognized academic medical center. The world-class hospital is focused on coordinated clinical care, expanded research activities and nurturing future generations of highly trained medical professionals.
Our commitment to nursing excellence has enabled us to achieve Magnet™ recognition by the American Nurses Credentialing Center. The Phoenix campus, long known for excellent patient care, has over 730 licensed beds, a number of unique specialty units and is the new home for medical discoveries, thanks to our collaboration with the University of Arizona College of Medicine
Phoenix. Additionally, the campus responsibilities include fully integrated multi-specialty and sub-specialty clinics, and with a new $400 million campus investment, a new patient tower and 2 new clinic buildings will be built.
About Banner Health
Banner Health is one of the largest, nonprofit health care systems in the country and the leading nonprofit provider of hospital services in all the communities we serve. Throughout our network of hospitals, primary care health centers, research centers, labs, physician practices and more, our skilled and compassionate professionals use the latest technology to make health care easier, so life can be better. The many locations, career opportunities, and benefits offered at Banner Health help to make the Banner Journey unique and fulfilling for every employee.
This position assesses, plans, implements, evaluates and documents nursing care of patients in accordance with organizational policies and in accordance with standards of professional nursing practice utilizing the framework for professional nursing practice and development. This position is accountable for the quality of nursing services delivered by self or others who are under their direction. This position utilizes specialized knowledge, judgment, and nursing skills necessary to assess data and plan, provide and evaluate care appropriate to the physical and developmental age of assigned patients.
Assesses patient physical, psychological, social, spiritual, educational, developmental, cultural and discharge planning needs. Reviews patient history and physical with patient/family and assures completion within appropriate timeframe.
Reviews available information obtained by other health care team members. Reviews diagnostics and laboratory data and reports abnormal results to the physician(s) and other appropriate caregivers. Completes assessment and reassessments according to patient need and as outlined in policy.
Formulates a plan of care, including the discharge plan, utilizing assessment data and patient, family and health team input. Initiates a plan of care based on patient-specific needs, assessment data and the medical plan of care.
Goals for patient are realistic, measurable and developed in conjunction with the patient/family. Considers the physical, cultural, psychosocial, spiritual, age specific and educational needs of the patient in the plan of are. Plans care in collaboration with members of the multidisciplinary team. Reviews and revises the plan of care to reflect changing patient needs based on evaluation of the patients status.
Implements the plan of care through direct patient care, coordination, delegation and supervision of the activities of the health care team. Provides care based on physician orders and the nursing plan of care, in compliance with policies and procedures, standards of care, and regulatory agency requirements.
Delegates appropriately, and provides nursing supervision in the provision of care to patients by other licensed nurses and other personnel. Promotes continuity of care by accurately and completely communicating to other caregivers the status of patients for whom care is provided.
Evaluates the patient's and family's response to care and teaching, and revises the plan of care as needed. Evaluates patient progress towards goals and expected outcomes in collaboration with other health care team members. Evaluates patient's response and the effectiveness of patient teaching.
Documents assessment, planning, implementation and evaluation in the patient record. Documentation is legible, timely and in accordance with policy.
Documentation reflects objective/subjective data, nursing interventions and patients response to treatment. Notes physician orders accurately and in a timely manner.
Provides care based on the best evidence available and may participate in research activities within clinical practice. Participates in unit or facility shared leadership.
Interacts and participates in the education, role development, and orientation of facility personnel, patients, students, families and visitors. Promotes/supports growth of others through precepting and mentoring when appropriate.
Contributes to society through activities that lead to excellent patient outcomes through timely, effective, efficient, equitable, and safe care. Actively participates in the improvement of national nursing quality indicators and outcomes. Such activities may include participating in professional organizations.
In some roles, this position may supervise staff and work flow of the department.
Must possess a current, valid RN license in state of practice, temporary/interim RN license in state of practice, or compact RN licensure for current state of practice. BLS certification is required. Additional certification or continuing education may be required based on area of practice.
Relates throughout the interview process the experience, training and education needed to perform the job. Experience in the clinical area for which he or she is applying is desired.
Must maintain clinical performance competencies appropriate to the area in which they work as demonstrated through annual validations. Banner Registry and Travel acute care positions require a minimum of one year experience in an acute care hospital setting. Experience must include working in an acute care setting within the past 12 months as a Registered Nurse in the specialty area. Banner Registry and Travel physician practice positions require a minimum of one year experience as a Registered Nurse in a physician practice or an acute care setting.
Bachelors degree preferred.Professional certification preferred.
Additional related education and/or experience preferred.
Administrative Assistant II - Stem Cell Transplant, Full-Time, Days
8am - 5pm
Greets customers and responds to general and specific inquiries that require advanced departmental knowledge and critical thinking skills. Independently collects information and coordinates preparation of reports.
Identifies and assesses issues and opportunities for improvement and implements changes following managerial review. Maintains department schedule by coordinating calendars for department personnel, arranging meetings, conferences, teleconferences and travel with minimal direction. In collaboration with Management, creates and maintains operating procedures and guidelines.
Reads, researches and routes correspondence: drafts letters and documents; collects and analyzes information and initiates telecommunications. Delivers and/or coordinates the delivery of documents and materials as required. Maintains equipment in good working order.
Records meeting discussions by attending meetings and recording key discussions and conclusions. Supports accounts receivable/payable processing. May perform other duties as assigned.
High school diploma or GED equivalent.
Two (2) to five (5) years' experience in a relevant role.
College studies and/or a minimum of two years providing office services (strongly preferred).
Basic understanding of Microsoft Office Software.
Cell Processing Specialist I
Staff members of the Cell Manipulation Core Facility (CMCF) perform a variety of tasks to provide the highest quality products for patients undergoing stem cell transplant and other cellular therapies. Members of this team also provide expertise in the transportation and shipping of cellular products both within the institute as well as to outside facilities. Staff must be competent in aseptic technique, clean room procedures and cGMP requirements for a cell therapy manufacturing laboratory.
Located in Boston and the surrounding communities, Dana-Farber Cancer Institute brings together world renowned clinicians, innovative researchers and dedicated professionals, allies in the common mission of conquering cancer, HIV/AIDS and related diseases. Combining extremely talented people with the best technologies in a genuinely positive environment, we provide compassionate and comprehensive care to patients of all ages; we conduct research that advances treatment; we educate tomorrow's physician/researchers; we reach out to underserved members of our community; and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.
Responsibilities Process human cellular products by various methods using manual and/or automated aseptic technique. Perform procedures consistently according to standard operating procedures and according to protocol specific instructions. Accurately and reproducibly generate expected results within established turnaround times. Achieve and maintain competency in routine procedures including:
centrifugation and washing,
storage in liquid nitrogen,
labelling and transportation.
Shipping and receiving
Review and evaluate test results for acceptability including automated and manual cell counts, viability results, flow cytometry histograms, sterility testing results when applicable. Maintain records of procedures and resultant data, both manually and on computer. Enter data correctly in electronic data capture systems. Evaluates/troubleshoot problems related to product analysis and preparation. Appropriately communicates outcomes. Perform environmental monitoring of work area and laboratory. Communicate effectively and professionally with other health care providers involved in the patient's care. Detect, troubleshoot, and correct instrument, reagent, and system failures. Perform preventive and corrective maintenance of equipment and instrumentation. Identify the need for repair or referral as required. Respond to REES alarm system alerts and document corrective actions appropriately. Maintain a safe and professional working environment. Other duties and procedures as required or assigned.
QA/Regulatory Duties and
Perform and document QC/QA activities as defined in policies & SOPs.
Recognize and report deviations from standard operating procedures.
Participate in validation of new instruments & methods.
Examine existing processes and problems and continuously look for process improvement.
Perform competency testing as required.
Work within the cGMP and cGTP guidelines and adhere to all regulatory standards within the Cell Manipulation Core Facility.
Additional duties and responsibilities:
Assist in validation studies, to include study design and implementation.
Membership in a professional organization.
Actively pursues continuing education opportunities.
BS/BA in a Biological Science, medical technology environment or related field preferred. Clinical laboratory experience preferred but not required. 0-2 years of experience acceptable.
Requires ongoing commitment to upgrade job skills.
Able to work closely with others and possess solid interpersonal and communication skills.
Capable of working in a fast-paced and rapidly changing environment.
Effective in an ethically diverse work group.
Capable of producing accurate results within strict time constraints.
Willing to accommodate schedule adjustments, as well as off-shift and weekend assignments as workload dictates.
Must possess good judgment, problem solving and analytical skills.
Ability to be flexible & adaptable to changing technology.
Attention to detail and interpersonal skills to effectively communicate with staff and physicians.
Good analytical reasoning & ability to perform complex mathematical calculations using scientific notation.
Clinical/research GCP knowledge.
Knowledge of lab safety and infection control.
Familiarity with operation & performance of basic lab equipment, i.e., centrifuge, microscopes, program freezers, etc.
Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other groups as protected by law.
Research Investigator, Cell Biology, Oncology Small Molecule Drug Discovery And Translational Sciences
Array BioPharma is a biopharmaceutical company headquartered in Boulder, Colorado that is focused on the discovery, development and commercialization of targeted small molecule drugs to treat patients afflicted with cancer. Array recently received approval and launched BRAFTOVI (encorafenib) and MEKTOVI (binimetinib) for the treatment of patients with BRAF mutated melanoma. These products have also been granted Breakthrough Therapy Designation by the FDA for BRAF mutated CRC.
This is a high-profile position within the organization. The individual will contribute to Array's mid-to-late stage preclinical drug discovery programs on both a strategic and tactical level. He/she will leverage their deep expertise in oncology cell biology to guide programs into the clinic by providing critical insight and key data to inform clinical strategy. Specifically, this individual will oversee the design and execution of compound mechanism-of-action studies both in vitro and in vivo, working with key internal stakeholders and external collaborators to inform patient selection, biomarker development and therapeutic combination strategies.
Identifies strategic and tactical challenges for each of the drug discovery programs that they support, helping to define, coordinate and execute on key experiments to address these challenges
Design and oversee studies to characterize the biological consequences of a given mechanism of action to enable generation of a robust clinical development plan to identify relevant cancer types, target patient population, potential combination strategies and mechanisms of resistance
Directly supervise and mentor group of 3-4 scientists (BS, MS and PhD) supporting multiple discovery programs
Maintain state-of-the-art technical knowledge base essential to building a deep molecular understanding of a compound's activity in cell lines, tumor xenografts and clinical samples
Work closely with external academic and industry partners to address key strategic questions related to developing a deeper understanding of how best to deploy specific mechanisms of action in the clinic
Contribute to written and oral presentations related to work being conducted for both internal and external presentation, regulatory submission and/or publication
Skills and Requirements
PhD with 8-10 years industry experience in small molecule drug discovery and translational science with a focus in Oncology
Strong familiarity with small molecule drug discovery from lead identification to candidate nomination with solid experience in all activities required to advance molecules into the clinic
Deep understanding of available and emerging technology platforms that can enable robust characterization of compound action in cells, tumor xenografts (including PDx and syngeneic tumor models) and human samples (e.g. blood, tumor biopsies, etc.)
Significant experience supervising, mentoring and developing the careers of scientists of all experience levels and educational backgrounds (BS-PhD)
Ability to effectively manage interactions with KOLs and academic and industry collaborators to identify, align around and execute on key objectives
Strong leader who understands their roles and responsibilities and works to empower their direct reports and project team members to contribute to the overall success of the efforts they support
Highly refined oral and written communication skills with the ability to effectively articulate key concepts to all levels of the organization as well as externally
Ability to work in a fast-paced environment with a high degree of independence to effectively address both strategic and tactical challenges, leveraging their solid understanding of cell biology and oncology
Recognized company-wide as a subject matter and/or technical expert in one or more areas
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