Cell Installer Job Description Sample
Research Associate - Cell Line Generation And Cell Culture
FVL59, Inc. is a privately held, early-stage biotechnology company leveraging novel insights in RNA biology to develop therapeutics for rare diseases and oncology.FVL59, Inc. was founded by Flagship Pioneering, an innovation enterprise that conceives, creates, resources, and grows first-in-category life sciences companies. The firm’s institutional innovation foundry, Flagship VentureLabs®, is where Flagship's team of scientific entrepreneurs systematically evolve ideas into new fields and turn previously undiscovered areas of science into real-world inventions and ventures. Flagship manages more than $2.3 billion in funds and, since 2000, the firm has applied its hypothesis-driven innovation process to originate and foster nearly 75 scientific ventures, resulting in $19 billion in aggregate value, 500+ issued patents and more than 50 clinical trials for novel therapeutic agents. These companies include Seres Therapeutics (NASDAQ:MCRB), Rubius Therapeutics (RUBY), Moderna, Syros Pharmaceuticals (SYRS), Axcella Health, Evelo Biosciences (EVLO), and Indigo Agriculture.
We are seeking Research Associates to join our team to develop and advance our research programs, from early discovery to proof-of-concept and beyond. We are searching for enthusiastic, innovative, and highly motivated individuals with a passion for pursuing innovative science aimed at bringing novel medicines to patients. Successful candidates should be scientifically motivated self-starters, comfortable working in a fast-paced entrepreneurial environment and capable of working independently in conducting and critically analyzing biology experiments. Research Associates will collaborate with VL59 scientists to complete key proof-of-concept studies and advance our technology platform.
- Full-time cell culture of mammalian cell lines, including fibroblasts, neurons, hepatocytes, iPSCs, and embryonic stem cells.
- Cell line engineering by transfection, viral transduction, CRISPR, RNAi, and degrons, to facilitate company objectives and meet experimental goals.
- Experimental assays and data recording of cell numbers, viability, doubling time, genotyping by PCR, and cell-type markers by flow cytometry.
- Lentivirus/AAV production and titration.
- Basic molecular biology preparations and experiments, such as RNA/DNA purifications, PCR/qPCR, western blots.
- Design, execution and troubleshooting of experiments as well as data analysis.
- Microscopy including Confocal imaging FISH, smFISH, IF.
- Maintain meticulous lab records, and report data and analysis to scientific and management team.
- M.S. or B.S. in Biology, Biochemistry or Molecular Biology or related field with 2+ years of research experience.
- Strong experimental skills with experience in cell biology, molecular biology, and assay development.
- Experience with mammalian cell culture, transduction/transfection techniques, and stable cell line generation.
- Experience with culture of primary cell lines, iPSCs, and embryonic stem cells.
- Experience with microscopy (IF, Confocal, FISH, smFISH), western blotting, qPCR/qPCR, molecular cloning, and RNA purification.
- Experience with flow cytometry a plus.
- Demonstrated ability to work with highly skilled teams in a fast-paced, entrepreneurial and technical environment
- Attention to detail and problem-solving skills
- Excellent communication and presentation skills, capable of conveying technical information in a clear and thorough manner.
Cell Specialist Ii/Iii - Cell Bank Production
The Cell Specialist II or III will participate and lead the manufacture of HEP & HDF cell banks under direct supervision from the department manager. He/she will perform and manage all tasks required to produce cells, i.e. tissue dissociation, spinner preparation, seeding, maintenance and harvest of cells, in a class 10,000 clean room environment in a safe and timely manner.
Activities will include production/expansion of cell banks, creation of test cells, senescence of Master Cell banks, and production of range finders and G100 range finders, for a smooth translation into production. With minimal supervision, he/she will be required to multitask by working independently while supporting and working with the team with on-going cell banking priorities. This position requires a high level of technical expertise in Cell Banking, Cell Culture, and Apligraf Production, thereby providing support to ongoing manufacturing operations. Strong values and behaviors and a sense of urgency for projects supporting Apligraf production are essential and required.
This position requires a high degree of manufacturing competence with a strong understanding of quality control and quality assurance concepts and the interrelation with cGMP manufacture of cellular products. This position involves close collaboration with process development, manufacturing, quality control, and quality assurance groups.
Knowledge and experience with equipment operation is required (e.g. incubators, controlled rate freezers, centrifuges, biosafety cabinets). Compliance to Standard Operating Procedure is essential to ensure that the cell banking and tissue processing suites are in compliance and operational at all times.
Dissociation of tissue and manufacture cell banks according to established procedures
Maintenance of cell bank inventory in compliance with AATB, FDA , state and local regulations
Adherence to all protocols, policies, regulatory requirements, cGMPs, and safety guidelines
Conduct batch record reviews with team and transfer to ensure that documentation is complete and in compliance
Harmonization with QC and Cell Culture for Cell Bank testing
Review/transfer of completed batch records to Quality Assurance in a timely manner
Proficiently operate equipment according to designed procedures
Maintain required records & adherence to established guidelines for quality control procedures, cGMP and safety
Assist in maintaining databases for trending, and analyzing cell culture technical data
Provide technical and operational support and problem solving capabilities, as needed
Coordinate the implementation of corrective measures to remedy deficiencies cited in audits of the manufacturing environment
Proficiently function within a Class 100,000 and/or Class 10,000 clean room environment, ensuring personal and product safety
Cell culture of mammalian cell banks using cell culture methods that may include T-flasks, cell factories, and spinner flasks, and cryopreservation of cell banks.
Responsible for ensuring all appropriate manufacturing documents are current and updated as required and that documentation is consistently produced with a high level of accuracy and clarity
Proven technical and scientific proficiency
Ability to communicate effectively with other departments
Performs additional duties as assigned
Weekend work/coverage is required, when necessary
Demonstrated expertise in manufacturing/aseptic techniques and GMP requirements
Proven organizational and documentation skills
Problem solving abilities
Excellent communication skills
Demonstrated leadership ability
Cell counting on a hemocytometer
Basic computer skills with a working knowledge of Microsoft Word and Excel
Ability to work independently as well as in a team environment
Ability to work in a cleanroom environment for extended periods of time
EDUCATION AND EXPERIENCE
Associate's Degree or Bachelor's Degree in the biological sciences with 3+ years of experience, or 5-7 years of experience in biotechnology or related field
Experience in aseptic technique and experience working in controlled clean room protocols highly preferred
Organogenesis Inc. Corporate Headquarters - Canton, MA 02021 US (Primary)
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Technical Program Manager, Das/Small Cell
How do you scale to multiple billions of users? From the patch of dirt, we build a data center on to the custom WiFi into employee's houses instead of needing to VPN, there is a lot behind facebook.com (http://facebook.com/). In honoring our hacker roots and challenging convention, we build the technical foundation of Facebook.
Facebook is looking to build its team focused on deployments of Distributed Antenna Systems and Small Cells at our corporate facilities around the world. A Technical Program Manager will have responsibility to build relationships and processes while ensuring success during planning, design, construction and handover phases of DAS/Small Cell builds globally. A successful candidate will help develop and understand requirements from internal customers and create solutions to improve productivity and services. A candidate must have a technical as well as a project/program management background, be innovative and agile, collaborate well in a team environment, and have very strong communication skills – a visionary who challenges the status quo and believes that collaboration technologies can level-up productivity.
- Oversight across the entire corporate DAS/Small Cell program at Facebook
Build processes that govern the design, procurement, and installation of in-building cellular systems
Find new efficiencies and process improvements in existing workflows while anticipating and mitigating potential problems
Analyze problems and devise solutions to roadblocks and unique challenges across dozens of cities and countries
Manage highly cross-functional site infrastructure projects in a matrix organization covering a range of internal and external areas (data centers, offices, multi-tenant facilities, mobile network operators, and more)
Identify operational pain points and opportunities to improve business practices and drive internal process improvements across multiple teams and functions
Review operational issues and determine if a technology solution is required or a process correction needs to be made
Conduct business process re-engineering reviews to innovate on business processes and define ways to improve their efficiency and effectiveness
Elicit detailed business requirements by engaging the business to capture clear functional design artifacts using techniques like use cases, data diagrams and process flow diagrams
Perform risk management and change management on projects
Establish metrics and build reporting based on those metrics for reporting to management
Work independently with minimal supervision
Ability to travel globally 20%
- B.S. in a technical discipline or equivalent experience
4+ years experience in Project or Program Management
2+ years experience working with DAS/Small Cell projects with an MNO or national integrator
Hands-on experience with DAS/Small Cell technologies
Hands-on experience deploying in-building solutions in corporate venues
Experience managing contracts with MNOs, integrators, and landlords
Knowledge of different signal source methods as well as emerging technologies
Experience with multi-carrier tenancy on neutral host DAS systems
- Functional knowledge of C-RAN and CPRI infrastructures
Experience with CommScope and SOLiD DAS equipment, including CommScope ION-E and Era platforms
Experience with iBwave
Experience working as a client-side project manager for DAS installations in corporate venues
Experience with sales, provisioning, or engineering at a major MNO
Experience with campus and enterprise networks and hardware
Research Associate/Research Scientist In Cell Culture And Discovery/Targeted Proteomics
The Moritz lab of the Institute for Systems Biology in Seattle, WA is seeking qualified Research Associates for its research at ISB.
Our current research directions include Targeted-protein quantitation using SRM, SWATH and Data dependent mass spectrometry biomarker discovery. Our projects include wellness, infectious disease, cancer, and aging biomarker development and validation in cells, tissues and blood, and complex mixture fractionation & enrichment, with a particular interest in the study of organ specific markers for markers signatures. In addition, we have at our disposal an array of mass spectrometers, including varieties of Thermo, Agilent and Sciex instruments for quantitative analysis.
The ideal candidate will have experience in mammalian and pathogenic bacterial cell culture within a BSL2 environment. The growth of mammalian cell lines and protein chemistry techniques to achieve purified protein extracts from secreted organelles or free proteins is required.
Experience in aseptic techniques and control of contamination is also required. Knowledge of biological mass spectrometry-based proteomics including liquid chromatography, computational identification of large data sets is preferred. Statistical analysis of data produced would be advantageous. We are looking for individuals with creativity, lateral-thinking, good communication skills and the willingness and ability to work as part of a larger multidisciplinary team of scientists.
ISB is an EOE (M/F/disabled/veteran status).
Registered Nuse (Rn) Car-T Cell Clinical Research
CAR T Cells Program
Methodist Hospital opened in 1963 as the first hospital in the now internationally acclaimed South Texas Medical Center. From the beginning, we've recognized the unique needs of each of our patients. It's a process that we continue to improve on, creating ways to better serve the community when they need us the most. With 981 beds, Methodist Hospital offers a broad range of specialties including cardiology, cancer care, bone marrow transplants, emergency medicine, neurosciences, maternity care, gynecology and orthopedics.
As the flagship hospital of the Medical Center and of the Methodist Healthcare system of hospitals, we appreciate the support and recognition we receive from the community having been ranked No. 1 in the Express-News Reader's Choice Awards. We also enjoy being the most preferred hospital in San Antonio, as consistently reported by the Consumer Research Corporation. Methodist Hospital has been nationally recognized by Leapfrog's Hospital Safety Grade A, accredited by the Joint Commission in stroke care, and designated as an accredited Chest Pain Center. For more information, please visit our website at http://www.sahealth.com/ and select Methodist Hospital under Locations.
The Research Nurse is responsible for coordinating and maintaining research protocols and data on patients participating in protocols that are authorized by Texas Transplant Institute Program. Candidate will understand the research study process as outlined by the Texas Transplant Institute Policies and Procedures for Research. Will be working on the CAR T Cell Program. This is a new treatment offering
BMT patients that have not had successful treatment. Costing $3million per patient to start treatment.
This is the next step for the right Oncology RN looking to expand their role.
Verbal and written communication skills
Analytical, problem-solving, and multi-tasking skills
Public presentation skills
Work independently in a fast-paced environment with minimal supervision
Manage multiple ongoing priorities and projects
Communicate and work effectively with a diverse team of professionals
Completion of a Registered Nurse education program
Bachelor Degree preferred
Oncology experience, preferably heme/onc and/or transplant
Experience in a clinical research setting preferred
Experience managing blood cancer and/or BMT clinical trials preferred
Certification or License:
Registered Nurse licensed in the State of Texas
Or a Compact State
Or Eligible to be licensed in the State of Texas as a Registered Nurse
Scientist, Cell Therapy Process Validation
Reporting to: Associate Director, Cell Therapy Operations
Location: Menlo Park, CA
Orchard Therapeutics is an international biotechnology company dedicated to bringing transformative gene therapies to patients with serious and life-threatening rare diseases. Orchard is a fast-growing and well-funded company with ground-breaking science and a broad pipeline that includes several products in late stage development and at least one BLA planned for the coming year.
The Cell Therapy Process Validation Scientist will lead activities for development, scale up, optimization, and validation of Orchard Therapeutics’ innovative gene-modified cell-based therapeutic products. Such activities will include process and assay development, cell therapy intermediate and final drug product formulation and stability evaluation, raw material evaluation, process scale-up / scale-out, and validation of manufacturing processes and controls to support company’s product programs from pre-clinical research through to commercial.
- Lead development, scale-up, optimization, and validation of cell isolation, cell culture, cell transduction and cell cryopreservation processes to include:
- Process and assay development, cell therapy intermediate and final drug product formulation and stability evaluation, raw material evaluation, process scale-up / scale-out, and validation of manufacturing processes and controls
- Compile, review and edit master production records, standard operating procedures, development/validation protocols and reports
- Perform FMEA risk assessments for cell therapy manufacturing processes
- Provide SME review of executed batch, records, test records and associated documentation for release of gene-modified cell therapy products. Support investigations.
- Co-ordinate activities with the research, pre-clinical development, QA, QC, clinical development and commercial departments to ensure the successful achievement of company timelines and milestones
- Prepare protocols and reports for prospective qualification and validation activities
- Ensure the successful execution of activities performed between departments and company designated collaborators and CMO’s
- Prepare CMC / CTD documents for regulatory filings with US and EU regulatory agencies
- Other activities as may be assigned
- B.S. or higher level degree in a scientific discipline preferred
- At least 5 years of experience in Regulatory Affairs, ideally in biologics
- Working knowledge and understanding of FDA regulations and guidelines
- Exposure to a global cross-functional team environment
- Excellent organizational skills and strong attention to detail; and ability to prioritize effectively and handle multiple tasks
- Strong interpersonal skills including verbal and written communication are essential in this collaborative work environment and to interact efficiently with Regulatory Authorities
The successful candidate will enjoy a competitive base salary and the opportunity to participate in incentive compensation programs, including an annual bonus and a stock option plan. Orchard Therapeutics, Ltd. offers a comprehensive benefits program, including: medical, dental and vision care; paid vacation and holiday time; and access to a voluntary 401(k) with company match. Orchard Therapeutics is an equal opportunity employer.
To apply for this role, or for further information, please email email@example.com
Notice to All Applicants: Orchard Therapeutics participates in E-Verify
Notice to RECRUITERS: All employment offers and CV’s are managed through our Human Resources Department and all candidates are presented through this avenue. Therefore, the Human Resources Department at Orchard Therapeutics requests that recruiters are not to contact Orchard Therapeutics employees directly to present candidates. Complying with this request will be a factor in determining future professional relationships with Orchard Therapeutics. Orchard Therapeutics will not accept unsolicited resumes from any source other than directly from candidates for either current or future positions. Submission of unsolicited resumes in advance of an agreement between the Human Resources Department and the recruiter does not create any implied obligation on the part of Orchard Therapeutics.
Research Associate, Cell And Molecular Biology
Founded in 2016, Foghorn Therapeutics discovers and develops novel drugs to treat cancer and other serious medical disorders. The company seeks to discover novel therapeutics that target chromatin remodeling complexes. Foghorn uses a proprietary platform based on revolutionary advances in mechanistic understanding of disease.
- B.S./M.S. with 1-3 years of relevant experience in oncology drug discovery, including cell assay development and target validation.
- Proven core competence in standard cell and molecular biology techniques.
- Excellent lab practice and versatility is highly required.
- Ability to think critically and creatively to solve problems.
- Commitment to quality, attention to detail, and team player mentality is a must.
- Work as part of an interdisciplinary team contributing to the design and execution of experiments that support our research activities and project goals.
- Design, conduct, and analyze data from experiment for target ID and validation.
- Establish and perform cellular assays to support drug discovery programs.
- Contribute to various aspects of company building, from scientific excellence to establishing a great company culture.
Media Development Scientist, Cell Culture
You will be a key member of our Bioprocessing team in our Cellular Agriculture department and essential in producing sustainable and cost-effective clean meat products. The position requires in-depth knowledge on animal cell culture process and media development. You will also partner with experts in cell biology, process development and process engineering teams to accomplish the above.
Responsible for Animal cell banking and testing (MCBs and WCBs).
Perform media component analysis and development (chemically defined, serum-free) studies to select suitable conditions for both cell line screening and cell culture process.
Perform biological assays (cell growth, viability, and clonal selection) with adherent and suspension cell cultures.
Collaborate with other functional groups including cell-line and analytical development teams for screening and characterization studies.
Perform systematic and thorough statistical data analysis to deduce clear conclusions.
Develop new assays for relevant areas.
Assist in scale-up/scale-down studies.
Author, review and support continuous improvement of batch records and SOPs
Mentor interns and research associates as required.
PhD in chemical / biochemical / biological engineering or related discipline with at least 1-3 years of experience in biotechnology / biopharmaceutical industry or MS in cell/molecular biology, biochemistry, bioengineering or closely related science with 5+ years of post-graduate research and development experience in the industry.
Proven technical experience in developing animal cell culture-based processes.
Proficiency in using design of experiments (DOE) in media and process optimization.
Experience in operation of bioreactors is plus.
Excellent technical writing, communication and presentation skills.
Ability to multi-task and meet aggressive deadlines.
Mission-driven, self-directed and enthusiastic about collaborating with an inter-disciplinary team of scientists and engineers.
Ability to pass a standard background check
Construction Manager - DAS And Small Cell (King Of Prussia, PA)
Our client offers a rewarding career track managing industry leading telecom projects with a growing organization along with future growth potential, excellent employee benefits, salary plus bonus, company vehicles to their employees, etc.
- Manage project schedules in the E.PA market and ensure deadlines are met.
- Oversea DAS projects in the field.
- Supervise Field Team and subcontractors to ensure quality work and safe work environment.
- Manage project budget.
- Experienced managing telecommunications projects that include DAS, Small Cell or tower NSBs / modifications.
- Leadership experience in the field and strong organizational skills.
- Self driven and positive personality.
Stanley Engineered Fastening, a Stanley Black & Decker Company, is a global leader in the development, manufacture, and sale of an extended line of metal and plastic fasteners and engineered fastening systems for commercial applications. We focus on total engineering solutions for end users' fastening requirements in the automotive, transportation, electronics, aerospace, machine tool, construction, and appliance industries. Our automotive division strives to lead the way with innovative solutions to ever changing customer challenges and opportunities. Within Stanley Engineered Fastening automotive division, an opening is currently available for Cell Set Up (Coldforming/header) at our Chesterfield, MI plant.
Basic Purpose and Objective
Under general supervision and according to established policies and procedures, sets up various sizes and types of cold forming and thread rolling machines to automatically shape and thread parts to blueprint specifications and set-up charts.
Specific Duties & Responsibilities:
Installs, thread rolling tooling and cold heading tooling in various machines.
Sets up, installs and calibrates various support equipment.
Computes feed length and progression, and establishes process parameters and sets monitoring equipment to insure processing parameters are maintained to produce quality parts.
Reads measuring equipment such as shadowgraph, micrometers, calipers, thread roll graphs, and related equipment, and documents on appropriate paperwork.
Performs minor tool modifications to include sharpening and adjustments to maintain integrity of parts.
Work overtime as required.
All other duties as assigned by supervisor.
- High school diploma or equivalent work experience.
Apply principles or rational systems to solve practical problems and deal with a variety of concrete variables in situations where only limited standardization exists. Interpret a variety of instructions furnished in written, oral, diagrammatic or schedule form.
Practical application of fractions, percentages, ratio and proportion, logarithms, slide rule, practical algebra, geometric construction, and essentials of trigonometry.
Stanley Engineered Fastening, a Stanley Black & Decker company is an Equal Opportunity Employer. All qualified applicants that apply for Stanley Black & Decker will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, national origin, disability or protected veteran status.
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