Cell Stripper Job Description Sample
The Set-up Operator title is an umbrella title that covers many specific job titles in the Set-up area. Ideally, under general supervision, each Set-up Operator should be trained and able to perform all of the subtitles under this umbrella title, which includes:
Layout Projection Operator, Letter Puller/Sorter, Pattern Puller, Pattern Tear Down, Polymer Machine Operator, Polymer Applicator, and Inspector. Please see specific functional job description for each of these positions for more specific information. As with all levels of production, employee works to assure accuracy and quality control. These duties promote the flow of materials necessary to production.
Cell Culture Technician, Pluripotent Stem Cell (Microbiology Resource I)
JOB TITLE: Cell Culture Technician, Pluripotent Stem Cell
- This work involves pluripotent stem cell culture and differentiation, selecting colonies, expanding selected clones, evaluating cell growth, calculating accurate cell viability and population doublings, maintenance of laboratory records, preparation and dispensing of media and cell culture supplements.
The ideal candidate for this role has an undergraduate degree in cell/molecular biology, biotechnology, or a related discipline.
We are primarily interested in meeting potential candidates who have exceptional aseptic cell culture technique with at least 1-2 years of particular experience in pluripotent stem cell culture
Cell Processing Specialist Car-T Cell Therapy - Morris Plains, NJ
Novartis is a global healthcare company based in Switzerland that provides solutions to address the evolving needs of patients worldwide. Novartis recently received the first ever FDA approval for a CAR-T cell therapy for children and young adults with B-cell precursor acute lymphoblastic leukemia (ALL) that is refractory or has relapsed at least twice; a novel immunocellular therapy, a one-time treatment that uses a patient's own T cells to fight cancer, and is the first therapy based on gene transfer approved by the FDA. Therapy will be manufactured for individual patients using their own cells at the Novartis Morris Plains, New Jersey facility where Novartis continues to advance its CAR-T manufacturing expertise. The Morris Plains site plans to hire over 300 Quality, Production, Supply Chain and Bioanalytics associates in the next 10-12 months.
Due to the nature of the starting materials (patient cells) the Cell processing Specialist role requires the highest level of proficiency and ownership. The Specialist will be responsible for end to end processing and verification of patient derived clinical and commercial cellular immunotherapy products.
Specific responsibilities will include:
End to end ownership for the processing of the assigned patient starting material in the clean room environment.
Maintain and prepare equipment/environment for use.
Document all steps in the assigned Batch record in line with GMP requirements.
Conduct all necessary processing/verification steps for the assigned lot with the highest skill level of aseptic technique.
Assist on Deviation Investigations, Change Controls, Safety Inspections and CAPAs.
Perform execution of assigned qualification/ validation activities.
Be responsible for successful on time completion of a required training curriculum composed of Global Operating Procedures (GOPs), Standard Operating Procedures (SOPs), Aseptic Techniques, Gowning Qualifications and other relevant training, including HSE for the specific role.
Perform other duties as assigned. Examples might be: successful completion of assigned PU project initiatives and/or work stream tasks, such as process improvements, efficiencies, Innovation Quality Productivity (IQP).
Maintain an "audit ready" module.
Selected associates must:
Be able to gown aseptically and work in a clean room environment (ISO 8, 7 and ISO 5) area for extended periods of time.
Be able to work with automated cell processing equipment such as Elutra, CS5, or Sepax.
Be knowledgeable in the use of production related IT systems such as SAP and MES.
Possess sound cell biological decision making. EEO Statement The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Minimum requirements •Bachelor's degree in relevant Engineering or Scientific discipline (preferred) or equivalent work experience. Advanced degree desired.
2-5 years' experience in cGMP cell culture manufacturing, experience in cell therapy manufacturing preferred.
Thawing cryo-preserved product.
Aseptic processing in ISO 5 biosafety cabinets.
Universal precautions for handling human derived materials in BSL-2 containment areas.
Cell expansion using incubators and single use bioreactors.
Cell washing processes, cell separation techniques and use of automated equipment.
Knowledge of cGMP regulations and FDA guidance applicable to biologics and cell therapy manufacturing.
Experience with SAP, MES, Trackwise, etc. preferred
Fluency in written and spoken English.
Ability to work a flexible shift is required.
Scientist I Single Cell Transcriptomic Approaches To Cell Types In The Mouse Nervous System
The Allen Institute for Brain Science, located in Seattle, Washington, is committed to understanding how the brain works and helping to unlock the mysteries of neurological diseases and disorders affecting millions worldwide.
The Allen Institute is seeking an exceptional candidate who will be part of a Seattle-based multidisciplinary team within the Cell Types Program. The successful candidate will participate in high-throughput single cell transcriptome data generation and analysis to support the effort funded by the newly awarded BRAIN grant from the NIH, which aims to define all cell types in the adult mouse brain. The candidate will be a Ph.D. graduate in life sciences or computational biology and will possess strong experimental and computational skills. She/he will collaborate with several other departments on the identification and classification of cell types in the mouse nervous system.
Work within the Molecular Genetics team on experimental design, execution, and research associate training in order to generate large-scale single cell transcriptome datasets.
Work with Modeling, Analysis and Theory team to timely and iteratively analyze single cell data from the internal single cell transcriptomics pipeline and facilitate generation of cell type taxonomy.
Design and execute validation and follow-up experiments to place the transcriptomics results in the neurobiological context.
Write and publish manuscripts, grant progress reports and grant applications.
Present work internally and externally at conferences.
Evaluate new single cell RNA-seq platforms and techniques.
Work with Electrophysiology and Neuroanatomy teams to facilitate data organization and integration in an effort to create multimodal neuronal taxonomy.
Ph.D. in life sciences or computational biology (e.g., Neuroscience, Genomics, Genetics, or related field).
Knowledgeable in genomic data generation from primary tissues (rodent handling, dissection, single cell collection, molecular biology, and next generation sequencing).
Knowledgeable about developmental neurobiology and systems neurobiology
Knowledgeable about RNA-seq, ATAC-seq and/or ChIP-seq data
Proficiency in R and Linux shell scripting.
2+ years of experimental experience in genomic data generation from primary tissues (rodent handling, dissection, single cell collection, molecular biology, and next generation sequencing).
2+ years of experience working in a rodent model system studying a neurobiological problem in vivo (e.g., developmental neurobiology, systems neurobiology).
2+ years of computational experience working with RNA-seq, ATAC-seq and/or ChIP-seq data, preferably at the single cell level.
Ability to develop, test, implement, and share new experimental and computational tools quickly, in an iterative manner, after feedback from experimental, data production, and analysis teams.
Experience with additional programming languages (Perl, Python, Matlab) preferred.
Exceptional oral and written communication skills.
Ability to work independently as well as part of a team to meet aggressive timelines in a collaborative environment.
It is the policy of the Allen Institute to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected by federal, state or local law. In addition, the Allen Institute will provide reasonable accommodations for qualified individuals with disabilities.
Fuel Cell Stack Unit Cell Research Engineer
Job Description: & Qualifications
Ford Research and Advanced Engineering is expanding fuel cell development activities at its Dearborn Research and Innovation Center and is seeking experienced PEM fuel cell stack unit cell research engineers. The positions will work closely with the supply base and focus on the design and development of unit cell designs and components such as bi-polar plates, seals, and integrated membrane electrode assemblies. This is an excellent opportunity for a highly qualified and motivated engineer to join a diverse team of researchers tasked with shaping and delivering Ford's future product strategy for fuel cell technology.
In conjunction with the supply base, develop unit cell, bipolar plate, seals, and/or integrated MEA designs
Develop and maintain design requirements, specifications, lessons learned, and best practices
Perform engineering analyses such as stress, pressure drop, heat transfer, fluid flow, geometric attributes, tolerance stack-up, etc.
Develop in-house models in support of unit cell design analyses
Develop and maintain quality documents such as P-diagrams, DFMEAs, etc…
Familiarity with stack cost estimating models
- Bachelor of Science in Chemistry or Bachelor of Applied Science in Chemical Engineering, Mechanical Engineering or Electrical Engineering
- 5+ years of relevant fuel cell unit cell design and integration experience with a major automotive manufacturer or as part of a major automotive manufacturer joint venture
Experience and/or knowledge in the following topics, Strong background in heat and mass transfer and fluid mechanics, FEA and CFD, Seal design and seal materials or Bipolar plate design, materials, and coatings
Experienced in the use of quality process tools such as P-diagrams, FMEA, 8D, etc.
Strong understanding of PEM fuel cell fundamentals
Experience with Six Sigma methodologies desired
Team player with strong interpersonal skills; able to work effectively in collaborative environment
Strong oral and written communication skills
The distance between imagination and … creation. It can be measured in years of innovation, or in moments of brilliance. When you join the Ford team you will discover all the benefits, rewards and development opportunities you'd expect from a diverse global leader. You'll become part of a team that is already leading the way, with ingenious solutions and attainable products – and it is always ready to go further.
Visa sponsorship may be available for this position.
Ford Motor Company is an equal opportunity employer committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race, religion, color, age, sex, national origin, sexual orientation, gender identity, disability status or protected veteran status.
Senior Mechanical Engineer – Cell Qualification And Cell R&D
This person's primary role will be ensuring current and future battery cell mechanical designs meet the requirements of Tesla's current and future battery modules, and vice versa. This person will work closely with Tesla's cell characterization and qualification team as well as battery module teams to design and execute mechanical methods that directly impact Tesla's product lifetimes and reliability. This role also involves working with module production teams to ensure cell requirements are met in actuality, not only by design. This person will work to qualify and iterate upon cell mechanical designs based on Tesla's needs and the capabilities of Tesla's cell suppliers. This person must exhibit the knowledge, leadership, and drive needed to not only challenge the status quo, but also define and execute the optimal path forward.
Design, develop, prototype, and execute mechanical test and characterization methods for battery cells and cell components
From first principles and experimental data, determine cell mechanical requirements such as maximum loads, limits of plastic deformation
Manage cell and cell-module interface requirements and work with validation teams
Be familiar with finite element methods (FEA) for mechanical modeling; work with FEA/modeling engineers to validate models and extract material parameters from mechanical tests that you have designed and performed
Produce meaningful and compelling analyses and data visualizations beyond Excel
Author technical presentations and summarize high-impact technical findings
Work in a laboratory and/or production environment, not just at a desk
Collaborate with and proactively build professional relationships with engineers, scientists, and technicians across different groups
Degree in Mechanical Engineering or similar
MS or PhD with 2+ years professional experience
BS with 4+ years professional experience
CAD; drafting; GD&T; tool / fixture / jig design
Design and execution of mechanical characterization experiments
Mechanical load frame operation, e.g. Instron, MTS, stress, strain, and creep measurements
Working with machine shops, rapid prototyping, and additive manufacturing
Building test fixtures using extruded aluminum framing and electromechanical parts e.g. pneumatic or solenoid actuators
Data acquisition systems; analog and digital signals
Extensive working knowledge of precision dimensional inspection tools
Working knowledge & relevant coursework in finite element analysis (FEA) methods
Ability to break down complex technical topics and deliver visual technical presentations (e.g. PowerPoint) to groups of engineers, scientists, and technicians
MATLAB, Python, LabVIEW, R
Mechanical testing of composite materials
Other materials test laboratory equipment
Ability to demonstrate a strong interest or passion for lithium-ion battery technology
Experience with mechanical testing of batteries
Knowledge of safety hazards of working with and mechanical testing of lithium and lithium-ion batteries
Please send most current resume and cover letter to PEControls@tesla.com
Scientist Cell Based Assays
Scientist, Cell Based Assays
(Thursday – Monday)
Independent scientist who demonstrates innovative technical knowledge and significantly contributes to the overall operations of the lab. Demonstrates strong oral and written communication skills and actively contributes to training, report generation and documentation. Demonstrates strong supervisory skills and contributes to the achievement of company and departmental goals and objectives. Performs and directs assays according to and in compliance with Good Laboratory Practice (GLP), current Good Manufacturing Practice (cGMP), Code of Federal Regulations (CFR) and/or Points to Consider (PTC) guidelines and Standard Operating Procedures (SOPs). Acts as Study Director as required
- Demonstrates innovative and independent scientific technical expertise and proficiency in scientific theory and rigorous practical application in the completion of laboratory procedures and development of new procedures as it relates to Analytical methods, flow cytometry and/or cell based potency assays.
- Designs and independently conducts scientific development projects from inception to completion
- Effectively communicates and defends science through written and verbal communication
- Provides training on areas of technical expertise and compliance issues relevant to the lab setting
- Conducts and directs assays and lab procedures according to and in compliance with GLP, cGMP, CFR and/or PTC guidelines and SOPs
- Accurately completes batch records and other required documentation according to and in compliance with GLP, cGMP, CFR and/or PTC guidelines and SOPs
- Prepares protocols, final reports, investigations, and deviations as needed
- Conducts critical review of results and reports data appropriately
- As assigned by Management, supervises personnel and assumes all associated responsibilities
- As assigned by Management, acts as Study Director, Lab Manager, and/or Principal Investigator for specific assays and assumes all associated responsibilities
- Effectively interacts with clients
- Maintains a laboratory notebook for Research & Development activities as required; reviews and signs laboratory notebooks
- Follows all general and laboratory SOPs
- Works on routine assignments per written procedures, where ability to recognize deviation from accepted practice is required.
- Normally receives minimal instructions on routine work and detailed instructions on new assignments.
- Ability to work in a team environment and independently as required
- May be required to work Holidays and weekends
- Contributes to the overall operations and to the achievement of departmental goals
Experience / Education:
- 8 + years of relevant experience or equivalent for Bachelors’, 5+ years for Master’s or 3+ PhD degree in Biological Sciences or related field or equivalent experience.
Knowledge / Skills / Abilities:
- Strong Technical and Scientific knowledge of protein based assays (i.e. ELISA, electrophoresis, etc), flow cytometry and/or cell based potency methods.
- Ability to use proficiently advanced laboratory equipment, such as, but not limited to; Flow Cytometers, automated cell counters, plate readers, HPLC, gel scanners, etc.
- Effective multi-tasking skills and time management required
- Ability to evaluate technical data and record data accurately and legibly
- Ability to accurately and reproducibly perform complex mathematical and statistical calculations
- Ability to use judgment as dictated by complexity of situations
- Ability to understand and follow verbal and demonstrated instructions
- Ability to clearly express and exchange ideas by means of verbal and written communication
- Ability to work effectively as part of a team and exhibit effective interpersonal skills
- Ability to work under limited supervision and to handle problems of a difficult nature
- Proficient in Oral & Written communication skills
- Must be able to work in Lab setting with Biohazards /various Chemicals
- Must be able to wear appropriate PPE.
- Must be able to work in environment with variable noise levels.
- Ability to stand or sit for long periods of time.
- Ability to perform light physical work, lifting up to 20 pounds as needed.
Equal Opportunity Employer Minorities/Women/Veterans/Disabled
Research Specialist C, Stem Cell Culture
The Gene Therapy Program (GTP) is entering a new era of unprecedented opportunity with great potential to reshape the face of medicine as we know it. Our discoveries have set the stage for successful treatments and possibly even cures for devastating genetic diseases.
The laboratory of Dr. Jim Wilson, at GTP of the University of Pennsylvania has been a leader in the development of innovative vector technology for close to three decades.
We have emerged as the 'go-to' organization for public and private partners, who want to participate in the gene therapy space. Currently we are positioned to lead another round of vector innovation and establish pre-clinical and clinical proof-of-concept in therapeutic applications of in-vivo genome editing.
We are currently looking Research Specialist C, to support research efforts in induced pluripotent stem cells (iPSCs) and disease modeling.
As a Research Specialist C, you will collaboratively plan and independently perform stem cell culture activities. You will be trained by Senior Research Investigator on in vitro and in vivo disease modeling. experiments under the management of a supervising scientist.
You will also aid other scientists in their research by performing biochemistry and molecular biology assays such as plasmid cloning and manipulation, PCR, western blot, and ELISA; cell biology assays such as flow cytometry, function assay of differentiated cells; animal manipulation such as xenograft, perfusion, and necropsy. You will be expected to keep abreast of the work of scientists within GTP, external research being conducted in the same field, and you will help in the preparations of presentations and writing of original manuscripts.
The experiments performed in this team will require individuals to work rotating weekends as part of their regular schedule.
Director, Global Marketing, Car-T Digital Cell Therapy Platform Lead
Other Locations:US- NJ- Summit East
Celgene is a global biopharmaceutical company leading the way in medical innovation to help patients live longer, better lives. Our purpose as a company is to discover and develop therapies that will change the course of human health. We value our passion for patients, quest for innovation, spirit of independence and love of challenge. With a presence in more than 70 countries, and growing - we look for talented people to grow our business, advance our science and contribute to our unique culture.
The Director, Global Marketing, CAR T Digital Cell Therapy Platform Lead will have a primary focus on the design, development and launch readiness of the CAR T digital cell therapy platform that will provide a cloud based end to end ordering solution for Celgene's CAR T therapies. This role will require close collaboration with the global CAR T commercial, regulatory, drug safety, manufacturing and supply chain teams. This role will be Summit based. The role of Director, Global Marketing, CAR T Digital Cell Therapy Platform Lead will report directly into the Global Commercial CART Lead.
Responsibilities will include, but are not limited to, the following:
Build and co-lead the cross functional team that will design, develop and ensure launch readiness of the global CAR T digital cell therapy platform
Deliver a flawless, best in class, customer focused integrated digital platform is available to support the launch of our CAR T therapies
Collaborate with global affiliate operational leads to ensure the platform customization required to meet local regulatory, compliance and legal specifications in all launch countries
Partner with CAR T manufacturing, supply chain and pricing and market access to ensure optimal integration of hub services within the platform
Collaborate with CAR T customers to identify the optimal integration of hospital based systems and services
Oversee all the factors that will contribute to the platforms success, communicating status while identifying and managing risks and issues
Prepare and assist global lead with commercial portion of program updates for governance committees
Manage consultants/agencies for key projects
Communicate the Global Market insights needs and ensure the initiation of market research projects with Global Market Insights
At least 7-8 years' industry marketing experience with 4+ years of digital marketing/platform experience; considered a leader in digital platform development
Comfortable with uncertainty and developing innovative new pathways with high expectations
Detail driven with excellence in managing multiple tasks concurrently under aggressive timelines
Ability to lead and motivate cross-functional teams, synthesizing diverse perspectives into cohesive, aligned recommendation/deliverables, managing dissension along the way and championing team recommendation with upper management across functional areas
Comfortable working within a large matrix organization and has a strong ability to navigate complex business structures
Demonstrated ability to think strategically and align and engage stakeholders to drive performance
Experience in delivering complex messages to various internal and external customers with a track record of effective and influential presentations
Ability to demonstrate Celgene Corporate Values through passion for the patient, courage to face our challenges and the unknown, trust in our words and our actions and excellence in delivering exceptional results
Critical Competences for Success
- Able to devise a long-term vision, based on a thorough understanding of industry trends and opportunities. Manages an effective planning process. Demonstrates creativity and effectiveness in addressing major strategic challenges.
Flexible & Entrepreneurial skills
- To develop an organization under expected heavy growth and extended product portfolio the ideal candidate must be able to navigate in a complex internal structure/environment and commit to the targets and deliver despite unforeseen events by;
Being able to think globally and act locally with sensitivity to cultural differences.
Recognizing market opportunities for both new and current products, act accordingly and take risk when opportunities arise.
Being a change agent in a rapidly transforming organization.
Being open-minded to new ways and new ideas.
- A top class team player. Works effectively in a team-based organization, collaborates cross-functionally and builds alignment around goals and objectives. Shares, circulates information. Readily builds consensus and achieves agreement on key initiatives and priorities. Will be able to point to previous success maximizing the communication requirements and productivity of a fast-growing leader company.
Analytical and problems solving skills
- Able to rapidly identify issues, develop and effectively implement solutions. Demonstrates personal flexibility and adaptability to operate effectively in changing environments and fluid markets.
- Proven ability to build, lead and motivate high performance management teams. Achieves organizational focus on key priorities, provides clear direction, delegates, actively communicates and coaches. Able to seek broad input from the FLT and the Global Marketing leadership teams regarding key decisions. Values diverse and opposing views. A committed mentor, people developer and team builder. Strong organizational and administrative skills. Possesses a sense of urgency.
- A result oriented individual, with a participative, high energy style, strong personal work ethic, intense focus on results and a bias toward action. Establishes clear expectations, objectives and priorities. Sets aggressive but achievable goals and consistently delivers. Diligently monitors progress and proactively addresses variances. Highly decisive and action-oriented.
Other Personal Characteristics
- Possesses unquestioned integrity and strong business ethics. Demonstrates a firm commitment to the company's beliefs, values and organizational goals. Committed to making a positive contribution to the organization. Has the reputation and record of achievement to establish trust and credibility with peers, subordinates, collaboration partners, and external constituents.
- Communication skills
- Excellent communication and interpersonal skills. Effectively leads meetings. Strong presentation skills in both small and large group setting. Excellent listener; seeks broad input and feedback; frequent and effective follow-up.
- Highly intelligent
- A focused thinker with superior analytical skills. A quick study in new situations. Strong planning and implementation skills.
Celgene is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Celgene complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Celgene in the U.S.
Cell Culture Operator
The primary role of the Manufacturing Operator is working on routine manufacturing assignments detailed in written procedures and batch records, where adherence with cGMP regulations and safety are required.
Works on routine manufacturing assignments per written procedures, where ability to recognize deviation from accepted practices is required.
Adheres to Good Manufacturing Practices and Standard Operating Procedures.
Checks raw materials. Assembles, cleans and sterilizes process equipment, monitors processes.
Completes work instructions and maintains clean room environment to comply with regulatory requirements.
Trains for proficiency in the operation of primary production equipment within the assigned functional area including process automation systems.
Work on assignments that are routine in nature where judgement is required in resolving problems and making routine recommendations.
Supports safe work environment.
Candidate must have good troubleshooting and mechanical skills. Demonstrated proficiency in common computer tools such a word processing, spreadsheet and web based applications. The nature of the position demands keen attention to detail. Demonstrates good interpersonal skills, is attentive and approachable. Maintains a professional and productive relationship with area management and co-workers. Prior evidence of successful participation on work/study teams where combined contribution, collaboration, and results were expected.
High school diploma is required. Knowledge of science generally attained through studies resulting in a B.S. in science, engineering, biochemistry, related discipline, or its equivalent is desired.
Work Environment/Physical Demands:
This position is located in a manufacturing facility with classified areas requiring appropriate personal protective equipment. This role will require contact with hazardous materials such as caustic, acid and steam. Frequent bending, twisting, squatting, kneeling climbing and reaching is required. Role also requires infrequent unassisted lifting (not to exceed 50 lbs.). Repetitive use of arms/hand/ wrists, grasping is also required. Position involves working shift, which includes weekends, holidays and overtime. The work environment involves activities in a manufacturing facility. The environment incudes limited exposure to noise (> 85 dBA), hazardous chemicals and equipment temperature extremes.
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