Crystallographer Job Description Sample
Principal Scientist, X-Ray Protein Crystallographer
Requisition ID: CHE005843
Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States and Canada, is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where Merck has codified its legacy for over a century. Merck's success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare.
Merck is on a quest for cures and is committed to being the world's premier, most research-intensive biopharmaceutical company. Today, we're doubling down on this goal. Merck Research Laboratories is a true scientific research facility of tomorrow, and will take Merck's leading discovery capabilities and world-class small molecule and biologics R&D expertise to create breakthrough science that radically changes the way we approach serious diseases.
This position within the Chemistry, Capabilities and Screening group at Merck Research Laboratories will support lead discovery and optimization through X-ray structure determination and interpretation of therapeutically important targets. The successful candidate will perform crystallization screening, crystal optimization, and structure determination of protein-ligand and antibody complexes and will work in collaboration with medicinal and computational chemists. The successful candidate will also work closely with molecular biologists and protein biochemists and will have access to cloning, expression, and crystallization technologies as well as a variety of instrumentation for biophysical analyses.
Productive and collaborative interactions with other members of the department, as well as with members of other departments are required. There is an expectation for periodic travel to other locations. Cooperative and collaborative use of internal and external expertise and established leadership skills will be essential to success. The position requires active interaction with the external scientific community to continually improve scientific understanding, including presentations at national or international meetings.
Consistently cited as an inspiring place to work, Merck employs talented people who discover, develop, manufacture, and market a wide range of vaccines and medicines to address unmet medical needs. Each of us is joined by an extraordinary sense of purpose bringing Merck's finest achievements to people worldwide. The Merck Kenilworth campus is located within commuting distance from New York City. This close proximity allows for close interactions with the New York City structural biology community, giving easy access to the latest developments in the field.
- PhD degree with a minimum of 8 years of experience in structural biology
8+ years of experience in the application of structural biology to drug discovery
Demonstrated ability to design and execute X-ray crystallographic structure determination projects
Understanding of biophysical or functional characterization methods and their use to drive structural biology projects.
Excellent communication skills and strong publication record
Evidence of leadership in the training and mentoring of team members and project management.
Ability to work effectively within timelines.
Experience in solving multi-protein complexes or in the use of state-of-the-art membrane protein structural biology.
Protein design and engineering to enable structural studies
Expression and purification of multi-protein complexes and membrane proteins
Experience with cryo-EM techniques is a plus.
Experience in overseeing the work of other PhD level scientists.
Scientific programing / method development for structural biology
Your role at Merck is integral to helping the world meet new breakthroughs that affect generations to come, and we're counting on your skills and inventiveness to help make meaningful contributions to global medical advancement. At Merck, we're inventing for life.
If you need assistance and/or a reasonable accommodation due to a disability during the application or the recruiting process, please send a request to email@example.com.
Search Firm Representatives Please Read Carefully:
Merck & Co., Inc. is not accepting unsolicited assistance from search firms for this employment opportunity. Please, no phone calls or emails. All resumes submitted by search firms to any employee at Merck via email, the Internet or in any form and/or method without a valid written search agreement in place for this position will be deemed the sole property of Merck. No fee will be paid in the event the candidate is hired by Merck as a result of the referral or through other means.
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Employee Status: Regular
Number of Openings:
Shift (if applicable):
Company Trade Name: Merck
Nearest Major Market: New York City
Nearest Secondary Market: Newark
Molecular Analytics Scientist
Bristol-Myers Squibb is a global biopharmaceutical company whose mission is to discover, develop and deliver innovative medicines that help patients prevail over serious diseases.
One shared journey is moving us forward at Bristol-Myers Squibb. Around the world, we are passionate about making an impact on the lives of patients with serious disease. Empowered to apply our individual talents and ideas so that we can learn and grow together. Driven to make a difference, from innovative research to hands-on community support. Bristol-Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees the resources to pursue their goals, both at work and in their personal lives.
Build a capability within Molecular Analytics that would serve multiple roles. This is based on our own strategy and positive feedback we received during the Chemistry IT/Cheminformatics breakout and survey we conducted a few years ago.
Anticipated Cheminformatician Role in the Strategy:
Embedded with a traditional CADD rep onto key projects.
Serve as an on-call resource for "expert data analysis" by project teams
Engage in machine learning & data mining for cross-project efforts & tools (e.g. matched pairs, liability models, deck enhancement, etc.)
Contribute to an emerging integration platform that will leverage data science,, cheminformatics, and bioinformatics for the identification and optimization of protein and small molecule therapeutics. Example workflows or tools include:
HTS data analysis for hit identification using statistical analysis, visual inspection, and structure/sequence interrogation
Annotated databases linking molecules to targets to pathways for use in target identification
Multiparametric design using structure-based or data mining models of key ADMET and selectivity endpoints
Machine learning and data mining models for leveraging matched molecular pairs, assay data, crystallographic databases, etc.
Visualizations and deep learning models of immunogenicity, stability, etc. for the design of protein therapeutics
In-depth knowledge of cheminformatics, computer-aided drug design, computational chemistry or computational biology;
A history of impact using computational approaches to drive scientific experiment and design
Strong knowledge of chemical and protein structure and sequence
Background in methods for statistical analysis, cheminformatics, bioinformatics, machine learning or data visualization
An aptitude and desire to learn and apply new techniques is expected
A basic knowledge of medicinal chemistry, biology and ADMET/PK
Personal attributes of integrity, creativity, problem solving, and strong work ethic
Ability to work within a multidisciplinary team across geographic areas to advance discovery projects
Excellent communication skills are a must
Ph.D. in Chemistry, Biology, or Computer Science with 0-3 years of postdoctoral experience or commensurate career experience
FMC Corporation is a leading speciality company focused on agricultural and lithium technologies. We are proud that our products help grow that world's food, improve health and contribute to a more sustainable energy supply.
FMC is a globally diverse organization that offers its employees exciting opportunities to work on challenging projects that are important to the achievement of our strategic objectives. Your education and professional experience are valued and put to use from day one. Your success at completing key initiatives can result in a varied, progressive and fulfilling career with FMC.
With a corporate culture of innovation, integrity, responsibility and customer intimacy, we foster "The Right Chemistry" in everything we do. We are looking for people to join us in creating, developing, and improving our products, our processes, and our markets. In short, If you are ready to make a difference every day, FMC is ready to talk to you.
FMC Ag Solutions, Research & Development is seeking a highly motivated scientist to help discover new products for the control of important agricultural pest species (weeds, fungi, insects) at our Newark, Delaware research facility. The candidate will be a member of the Chemical Genomics Group in Discovery Biology working with a multidisciplinary team of researchers supporting a gene to chemistry process comprised of isolating and validating biochemical targets for discovery of novel small molecule synthetic starting points.
Applicants should have post-doctoral and industrial experience investigating and determining the mechanisms of enzyme or receptor mediated reactions, such that any proposed partial reaction or transition state intermediate could form the basis of focused synthesis programs. The candidate should be familiar with assay development for high-throughput screening to identify novel active entities. They should also be familiar with using crystallographic information to assist design concepts. Demonstrated skills in the following areas are therefore required:
Development of robust enzyme/receptor assays suitable for high-throughput screening.
Ability to deconvolute biochemical mechanisms.
Design inhibitors based on mechanistic and structural information.
The successful applicant will be a proven problem solver, possess good analytical skills, and be capable of working effectively in teams composed of molecular biologists, synthetic and analytical chemists, computer modelers, and biologists.
Ph.D. degree in biochemistry, molecular biology
Demonstrated experience (3 + years) in assay development.
Experience dissecting enzyme/receptor mechanisms.
Experience with standard methods of cloning, expression, and purification of proteins.
Experience with inhibitor design.
Good publication record.
Excellent project management skills and flexibility in research direction.
Excellent oral and written communication skills.
Strong interpersonal skills and ability to work with interdisciplinary teams.
Mentoring and training associates.
The following skills are desirable, but not essential:
Experience of synthesizing designed inhibitors
Isolation of membrane associated proteins
Some familiarity with either fungal, insect, or plant biochemistry
FMC employees enjoy competitive compensation, a menu of work/life benefits and opportunities to continue developing their skills and building their career. FMC is an Equal Opportunity Employer and makes employment decisions without regard to race, gender, disability or protected veteran status. FMC supports a drug-free workplace.
The Director of X-Ray Core laboratory provides leadership and direction in the management of research and experiential learning activities that involve the X-Ray Core laboratory. He/she supports the instructional and research mission of the Chemistry Department through faculty and student engagement by providing support, consultation and expertise in X-Ray experiment and instrument functionality to accomplish the department's instructional and research goals.
This includes experimental design and execution, project evaluation, data analysis, student training, and education. The major responsibilities of the X-Ray Core laboratory Director include (1) manage operation of the X-ray Crystallographic laboratory including design and use of the laboratory for experiment selection, implementation and analysis; (2) train and collaborate with students and faculty to determine the structure of small molecules by X-ray crystallography for experiments and education. The Director will also provide crystallographic expertise to further the department's instructional and research goals.
This position may also provide opportunities for lectures in X-ray Crystallography and other Chemistry courses. This would be accomplished through a secondary faculty appointment. Three or more years' experience operating and maintaining modern diffractometers, mounting single crystals, and solving small molecule data sets.Ph.D. in Chemistry, Physics, or related area. Demonstrated experience in crystallographic studies or equivalent research experience.
Department: 236179 - Biophysics
Full/Part Time/PRN: Day Job
The Structural Biology Laboratory at UT Southwestern Medical Center currently has two openings at the non-tenure track Research Assistant Professor level for highly-motivated individuals who enjoy working in a collaborative, multi-disciplinary setting.
Position #1:Cryo-electron microscopist with extensive experience in high resolution single-particle reconstruction, including sample grid preparation, data collection, the use of modern software for particle picking and classification, map generation, model building and structure validation.Experience in cryo-EM tomography is a plus.
Position #2:X-ray crystallographer with extensive experience in modern methods of crystallization, data collection using home and synchrotron sources, structure solution via various experimental techniques, refinement and structure validation.
For both positions, a Ph.D. in biochemistry, chemistry, physics or a related field is required. Facility with related techniques for each position such as cryo-electron microscopy, X-ray crystallography, NMR, small-angle X-ray scattering, isothermal titration calorimetry, analytical ultracentrifugation and protein expression and purification is highly desirable.
Job requirements include a significant amount of both formal and information teaching, and job experience is highly desirable. Salary is competitive and commensurate with experience and qualifications.
About the UT Southwestern Structural Biology Laboratory
The Structural Biology Laboratory (Diana Tomchick, Director) is a platform that allows researchers with different expertise to come together in a collaborative setting and tackle biological problems in a comprehensive way. Our publications are representative of the success of this strategy: http://www3.utsouthwestern.edu/sbl/Publications.html.
State-of-the-art equipment is currently installed, operational and shared between the members in the Structural Biology community at UT Southwestern. Cryo-EM equipment consists of one 300 kV Titan Krios microscope, one 200 kV Talos Arctica microscope, and a cryo-Scios DualBeam for cryo-FIB-milling.
In addition, the Structural Biology Laboratory has a dedicated lab for cryo-EM grid preparation, with an FEI Vitrobot and assorted instruments for sample prep. Computational facilities include a campus high-performance computing cluster. Crystallographic equipment includes an Art Robbins Gryphon crystallization robot and a Scorpion liquid handling robot, a Jansi UVEX UV microscope, a Rigaku FRE superbright rotating anode X-ray generator with an ACTOR sample mounting robot, and 30 days of guaranteed synchrotron beam time at Sector 19 of the Advanced Photon Source.
These facilities are supplemented by a variety of biophysical instruments supporting the study of macromolecular using NMR, CD, dynamic light scattering, analytical ultracentrifugation, stopped-flow kinetics, isothermal titration calorimetry, microscale thermophoresis and mass spectrometry.
UTSouthwestern Medical Center is committed to an educational and working environment that provides equal opportunity to all members of the University community. In accordance with federal and state law, the University prohibits unlawful discrimination, including harassment, on the basis of: race; color; religion; national origin; gender, including sexual harassment; age; disability; citizenship; and veteran status. In addition, it is UTSouthwestern policy to prohibit discrimination on the basis of sexual orientation, gender identity, or gender expression.
Materials Mechanics Research And Development Scientist (Experienced)
What Your Job Will Be Like
We are seeking a highly motivated, high-performing materials scientist to perform cutting-edge research and development on materials and components for national security applications. This position offers the opportunity to work with leading scientists and engineers in materials science in a state-of-the art experimental facility, with a strong focus on scientific development to improve understanding of structural metals. A large portion of current work is in the development and characterization of metals and processes for additive manufacturing (AM)/3D printing of load-bearing/structural parts. The Department uses state-of-the art equipment and technology for materials mechanics characterization, such as a high-resolution Electron Back-Scatter Diffraction technique for measuring residual stress, strain and dislocations. Other work on AM metals includes quantifying shape distortion, residual stress, strength, ductility, and surface finish. Another significant portion of the job will be consultation with engineers on additively manufactured and conventional components.
On any given day, you may be called on to:
Work with researchers from diverse backgrounds to design and perform laboratory experiments
Analyze data in Matlab, Minitab, Excel, and other specialized scientific software
Advise design engineers on appropriate materials, geometry, etc. for a given application
Develop experiments for model inputs and validation
Contribute to publications in peer-reviewed journals and present in scientific forums
Qualifications We Require
PhD in Materials Science or Materials Engineering, or a closely related field
Experience with materials science and structural behavior of metals
Experience with experimental techniques for measuring structural properties and microstructural characterization
Good communication skills as evidenced by a history of publication of results in peer-reviewed journals and external presentations at appropriate scientific conferences
Ability to obtain and maintain a DOE Q clearance
Qualifications We Desire
Experience with mechanical testing, for example, familiarity with load frames such as the MTS system
Familiarity with Electron Back-Scatter Diffraction (EBSD) analysis, secondary and transmission electron imaging, and other microscale and crystallographic techniques
Experience in high-temperature mechanical property measurements and analysis
Experience with Digital Image Correlation
An understanding of material mechanics including stress tensors, plasticity, rate effects, etc.
About Our Team
The Materials Mechanics and Tribology Department supports mission areas including Nuclear Weapons, Defense Systems, Energy, and Biological Sciences. The department provides its customers with:
Solutions to problems involving mechanical properties of materials, both bulk properties and surface or tribological properties
Relationships and dependencies among materials structures, composition, properties, performance, reliability and service environments
Diagnostics and modeling that enable deep scientific investigations of material behavior and prevention of failure
Scientific discovery and peer-reviewed publications on material mechanics and tribology.
Sandia National Laboratories is the nation's premier science and engineering lab for national security and technology innovation, with teams of specialists focused on cutting-edge work in a broad array of areas. Some of the main reasons we love our jobs:
Challenging work with amazing impact that contributes to security, peace, and freedom worldwide
Some of the best tools, equipment, and research facilities in the world
Career advancement and enrichment opportunities
Flexible schedules, generous vacations, strong medical and other benefits, competitive 401k, learning opportunities, relocation assistance and amenities aimed at creating a solid work/life balance*
World-changing technologies. Life-changing careers. Learn more about Sandia at: http://www.sandia.gov
- These benefits vary by job classification.
Position requires a Department of Energy (DOE) granted Q-level security clearance.
Sandia is required by DOE directive to conduct a pre-employment drug testing, and a pre-employment background review that includes personal reference checks, law enforcement record and credit checks, and employment and education verifications. Applicants for employment must be able to obtain and maintain a DOE Q-level security clearance, which requires U.S. citizenship.
Applicants offered employment with Sandia are subject to a federal background investigation to meet the requirements for access to classified information or matter if the duties of the position require a DOE security clearance. Substance abuse or illegal drug use, falsification of information, criminal activity, serious misconduct or other indicators of untrustworthiness can cause a clearance to be denied or terminated by the DOE, rendering the inability to perform the duties assigned and resulting in termination of employment.
Equal opportunity employer/Disability/Vet/GLBT
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