Monomer Purification Operator Job Description Sample
Lead Water Purification Plant Operator
This position requires a demonstrated ability to perform advanced functions related to the operator and maintenance of equipment at all water treatment facilities. This position functions as a Lead Operator and also as Chief Plant operator when required, performing complex analysis of the Water Treatment Plant operations and having direct charge of the operation of a water treatment facility or Water Production Facilities. Positions at this level provide instruction and assistance to lower level Water Treatment Plant Operators. This position is normally filled by advancement from the Water Treatment Operator II. Position requires three to five years of experience in a Surface Water Treatment Plant Operator and must possess a minimum of a Class 'C' Surface Water Treatment Plant Operator Certificate issued by the Texas Commission on Environmental Quality at the time of accepting position.
Essential Job Duties:
Incumbents may not perform all of the list duties and/or may be required to perform additional or different duties from those set forth below to address business needs and changing business practices.
Operates the water treatment plant including related subsystems and instrumentation.
Monitors the treatment process from the control board/computer screen; monitors various treatment processes including coagulant feed, rapid mix, flocculation, sedimentation, filtration and disinfection; monitors the addition of chemicals added for taste and odor control.
Monitors water quality by performing laboratory tests at various stages in the treatment process including tests for chlorine residual, ph, turbidity, hardness, alkalinity, odors and other tests as necessary to maintain water quality; calibrates laboratory equipment; maintains laboratory records.
Determines chemical dosage and makes adjustments to plant processes as necessary including for ferric Sulfate/Aluminum Sulfate, chlorine, ammonia, potassium permanganate, caustic soda, powdered activated carbon, and other chemicals.
Reads gauges and meter; interprets data to maintain the proper treatment process, proper distribution operation, security, and alarm status; make flow adjustments.
Operates pumps and valves utilizing a SCADA system; monitors systems for alarms, make adjustments, and provides appropriate response; notifies Plant Management or appropriate staff as necessary to respond to problems.
Operates mechanical equipment including pumps and motors, chemical feed pumps and systems, air compressors, and manual, electrical, and pneumatically operated valves; operates hard and power tools; operates a light truck.
Operates chlorination equipment related to the chlorine performs maintenance on chlorine system including chemical piping system; participates in calibration of chemical feed equipment.
Orders chemicals, Inventories and takes delivery of bulk chlorine.
Maintains operational logs and records.
Makes visual inspections; monitors facilities and roads to insure adequate security.
Performs preventative and predictive maintenance on treatment plant equipment; assists Maintenance personnel in making major and/or specialized repairs to equipment; coordinates work of contractors and of other departments.
Operates the City's water production system including elevated and ground storage and pump stations; ensures adequate availability and pressure to all service connections.
Provides appropriate response to emergencies and spills including those involving hazardous materials; wears respirators including self contained breathing apparatus as required.
Responds to inquiries from the vendors, suppliers, and public; answers questions from customers pertaining to water quality, low pressure, and leak reports.
Supervises and Trains operators.
Performs related duties as assigned or required
Physical and Environmental Conditions:
The conditions herein are representative of those that must be met by an employee to successfully perform the essential functions of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential job functions.
Environment: Water treatment plant. Exposure to noise of plant machinery and other equipment; mechanical and electrical hazards of operating equipment; fumes and odors of chemicals and gases; toxic substances such as chemicals, cleaners, solvents, and gases; all types of weather and temperature conditions. Work and/or walk for long periods of time on various types of surfaces including slippery or uneven surfaces and rough terrain. Subject to 24-hour emergency callbacks and requires working varying hours, overtime, weekends, and holidays. Work environment is informal, team-oriented, having both routine and variable tasks with variable pace and pressure. Work is performed in both indoors and in plant area and outdoors in field and collateral facilities.
Physical: Primary functions require sufficient physical ability to work in a plant and field setting and operate assigned equipment. CONTINUOUS walking, balancing, bending, stooping, kneeling, crouching, lifting of objects weighing up to 10lbs from below waist level to above shoulder level and transporting for distances up to 100 yards, fine finger dexterity to operate tools and controls, firm grasp to lift and carry objects; FREQUENT sitting, standing, reaching, twisting at waist, upward and downward flexion of neck, side to side turning of neck, lifting of objects weighing 11-25lbs from below waist level to above shoulder level and transporting up to 100 yards; OCCASIONAL climbing, pushing/pulling, lifting of objects weighing from 26-50lbs from below waist level to above shoulder level and transporting for distances up to 10 yards; INFREQUENT crawling, lifting objects weighting from 51-100lbs below waist level; with assistance, and transporting for distances up to 10 feet with assistance. Must be able to climb 150+ foot ladder and work effectively at the height.
Other: Safety regulations prohibit Operators from wearing contact lenses when working with certain chemicals or from wearing beards or other facial har that prevents a proper respirator fit. Must pass annual respirator physical and fit testing.
The following generally describes the knowledge and ability required to enter the job and/or be learned within a short period of time in order to successfully perform the assigned duties.
Operations, services, and activities of a water treatment system.
Principles, practices, materials, chemicals, and operating procedures related to operation and maintenance of a water treatment plant.
Operating principles of plant equipment including valves, pumps, and motors.
Methods and techniques of reading and interpreting gauges, recording devices, and related monitoring systems.
Tools and equipment used in the operation and maintenance of water treatment plant facilities.
Maintenance and repair principles and practices including preventatvie maintenance procedures.
Emergency maintenance and repair procedures related to water treatment facilities.
Methods and techniques of conducting laboratory tests and procedures related to water treatment analysis.
Mathematical calculations used in the water treatment operations.
Hydraulic and distribution principles.
Pertinent federal, state, and local laws, codes, and regulations.
Operational and safety regulations pertaining to water treatment plant operations.
Occupational hazards and standard safety precautions.
Principles and procedures used in the proper handling of chemiclas.
Principles and practices of customer service.
Office procedures, methods, and equipment including computers and applicable software applications.
Principles and practices of record keeping
Principles of training.
Operate, monitor, and maintain a variety of water treatment plant equipment, facilities and systems.
Perform complex inspections and preventive maintenance of treatment plant facilities and equipment.
Read and interpret gauges, meters and other instrument readings and take effective course of action.
Diagnose complex operational problems and perform effective maintenance on equipment.
Respond to changing demands on water flow, water quality, and equipment requirements.
Monitor and adjust plant processes.
Compile and record complex data and material.
Work well with others in a team environment.
Complete work within an assigned time frame.
Perform math calculations related to water works.
Operate assigned equipment and tools in a safe and effective manner.
Operate office equipment including computers and applicable software applications.
Work independently in the absence of supervision.
Demonstrate an awareness and appreciation of the cultural diversity of the community.
Communicate clearly and concisely, both orally and in writing.
Establish and maintain effective working relationships with those contacted in the course of work.
Education and Experience: High School Diploma or GED required supplemented by TCEQ training courses in the Surface and Ground Water related fields also management training is highly desirable.
Experience: Three to Five years of experience in a Surface Water Treatment Plant Operator.
License or Certificate: Possession of a Class 'C' Surface Water Treatment Plant Operator Certificate issued by the Texas Commission on Environmental Quality Required. Must be able to obtain and acquire a valid class 'B' Water works license issued by the Texas Commission on Environmental Quality within (2) years of accepting position. Possession of a valid Texas Class C Texas driver's license is required.
Senior Scientist, Protein Purification
The primary purpose of this position is to design, plan, and execute the diverse purification / recovery operations required for the production of the various vaccine candidates. These include development of scalable purification processes for native and recombinant proteins (soluble, membrane-embedded) using broad range of fractionation methods (centrifugation, ultra / diafiltration, etc.), and chromatographic techniques (affinity, ion exchange, hydrophobic interaction, immobilized metal, and mixed mode chromatography). Careful documentation of work and presentation of data is required. All work is to be done in a compliant manner according to SOP guidelines and cGMP/GLP regulations, where applicable.
Develop, optimize, and scale-up recovery/purification processes for isolation of vaccine candidates up to pilot plant scale.
Continuously evaluate each process and technique to assess its robustness, suitability and scalability. If necessary, introduce required modifications and improvements.
Collaborate with colleagues within Vaccine Research and Development organization including Bioprocess Fermentation, Analytical, and Formulation Development groups.
Present problems and propose solutions in discussions with group members. Offer insights based on experience to group members to help solve existing problems.
Plan and prioritize related recovery / purification activities.
Coordinate purification activity support and serve as a point person for the Process Development group when required.
Independently analyze, interpret, and provide conclusion and present experimental data.
Author and review purification procedures and reports.
Represent the process development group in relevant project sub team meetings, as required. Maintain detailed records and keep management informed as to the progress or issues.
Keep abreast of scientific/ technological development by participating in scientific meetings/ seminars and through regular scientific review. Utilize new technologies and establish those technologies to improve purification / recovery capabilities of process development group.
Where applicable, perform job responsibilities in compliance with GLP and all other regulatory agency requirements
Satisfactorily complete all GLP and safety training in compliance with departmental requirements and follow appropriate safety practices in the workplace
Perform timely notebook entries and review for completed experiments.
Perform other duties as assigned
The incumbent advises the supervisor of the equipment and consumables required to accomplish the work.
PhD in Biochemistry or related discipline with 0-4 years of academic, pharmaceutical, or biotechnology postdoctoral experience is necessary, or a relavant MS degree with minimum of 7 years relevant experience
A strong background in protein biochemistry, biophysics, and separation techniques is essential. Hands on experience with various classes of proteins is preferred.
Experience isolating/purifying proteins from both microbial and mammalian systems is preferred
Proficiency with personal computers including word processing, spreadsheets, PowerPoint and relevant scientific software is desirable. Strong verbal and written communication skills are required.
Knowledge and ability to independently design, plan, and execute purification / recovery activities. These should also include the ability to operate and maintain relevant instruments, resolve technical problems related to instruments, and execution of analytical / biophysical characterization methods.
Proficiency and ability to utilize various techniques such as FPLC / HPLC, UV-Vis, CD, fluorescence spectroscopy to isolate and, when necessary, characterize purified vaccine candidates.
Independently analyze and provide conclusions regarding experimental data generated
May also lead / direct junior colleagues within the group and facilitate scheduling of related activities to complete assigned tasks.
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.
Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.
Other Job Details:
Eligible for Relocation Package
Eligible for Employee Referral Bonus
Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.
Scientist II - Purification
Job Description: Job ID: PAL001672
Pall Corporation is a global leader in high-tech filtration, separation, and purification, serving the diverse needs of customers across the broad spectrum of life sciences and industry.
Pall Life Sciences provides cutting-edge products and services to meet the demanding needs of customers discovering, developing and producing biotech drugs, vaccines, cell therapies and classic pharmaceuticals. Pall offers advanced medical technologies, which are often a patient's last line of defense from dangerous pathogens. Pall's food and beverage products provide critical protection from contaminants during various manufacturing steps.
Pall Industrial serves a diverse range of customers in the microelectronics, aerospace, fuels, petrochemical, chemical, automotive, and power generation industries. Pall is a key supplier to the innovative and demanding semiconductor and consumer electronics industries, and provides filtration products used in critical applications on commercial and military aerospace vehicles. Pall products are key to the reliability of industrial equipment. Pall's engineered solutions help municipal and industrial customers address mounting water quality, scarcity and demand issues, and help energy companies maximize production and develop commercially successful next generation fuels.
Headquartered in Port Washington, New York, Pall has offices and plants throughout the world.
To learn more about Pall, please visit www.pall.com/green.
The position has the responsibility for performing downstream purification processes for monoclonal antibody and virus production. The individual will focus on purification activities in the laboratory, developing processes from material produced in bioreactors through a rigorous scientific / engineering approach in a conjunction with senior team members. The candidate ideally has experience in bioprocessing, and more specifically, with bioreactor monoclonal antibody and viral vector production processes. The individual must be competent in the analysis and interpretation of data, and will ideally have experience with analytical technics used for protein and virus characterization. The candidate will present data to collaborators and will assist in writing memos, protocols and reports by organizing data and observations.
Planning and execution of experiments for Pall downstream process development services including, continuous bioprocessing systems, depth filtration, chromatography, TFF testing along with some of the analytics
Prepare project summaries, by combining all data from a specific project from multiple individuals.
Help with administrative functions for projects – preparation of report drafts, budget tracking, draft proposals
Bachelors in biological science / chemical engineering & minimum of 6+ years of experience in protein purification or MS in biology / chem engineering & 4+ years of experience in protein purification
Experience with purification of monoclonal antibodies and expressed proteins, experience with viral particles is a plus (gene therapy and/or vaccine fields)
A good understanding of protein purification mechanisms and basic protein analysis tool (gels, ELISA)
Prior experience compiling information into technical reports
Ability to solve moderately complex issues independently
Strong computer, scientific, and organizational skills
Ability to handle multiple tasks with good organizational skills
Skills and Knowledge:
Plan and execute experiments for DSP, analyze data
Performance of required analytic assays, possibly including gels, ELISA, qPCR, protein glycosylation mapping.
Analyze project results and summarize for discussion with team. Make recommendations for further optimization
Help with administrative functions for assigned projects – including preparation of reporting docs, etc. (10%)
Ability to communicate effectively
Strong team oriented work style
Self-starter w/ ability to execute technical tasks and projects with minimal supervision
Computer literate (Word, Excel, PowerPoint)
Abilities to adequately record, analyze and document analytical data
Ability to reproducibly follow established procedures and critically analyze data using statistical tools.
Ability to work effectively with cross-functional groups.
Good hands-on and productive in the laboratory.
Comfortable working with outside customers in meetings and presentations
Danaher Corporation Overview
Danaher is a global science & technology innovator committed to helping our customers solve complex challenges and improve quality of life worldwide. Our world class brands are leaders in some of the most demanding and attractive industries, including life sciences, medical diagnostics, dental, environmental and applied solutions. Our globally diverse team of 62,000 associates is united by a common culture and operating system, the Danaher Business System, which serves as our competitive advantage. We generated $16.9B in revenue last year. We are ranked #133 on the Fortune 500 and our stock has outperformed the S&P 500 by more than 1,300% over 20 years.
At Danaher, you can build a career in a way no other company can duplicate. Our brands allow us to offer dynamic careers across multiple industries. We're innovative, fast-paced, results-oriented, and we win. We need talented people to keep winning. Here you'll learn how DBS is used to shape strategy, focus execution, align our people, and create value for customers and shareholders. Come join our winning team.
Development Associate Protein Purification
The primary responsibilities of this role,
Development Associate Protein Purification, are
to: Perform and conduct routine bench scale
purification development experiments (e.g. buffer preparation,
chromatography, tangential flow filtration, unit operation
procedures, assays, etc.) with general guidance and
instruction; Execute pilot scale production runs and supports
clinical manufacturing operations (equipment cleaning,
chromatography processing, tangential flow filtration, etc.) under
GMP conditions that are of a moderate complexity with limited
instruction; Act as operator in both development and pilot scale
manufacturing environment to represent department on project
teams; Communicate scientific findings and make
recommendations within the project team and within the
department; Contribute to the functions of the laboratory
including ordering, organization, chemical and equipment
monitoring, and equipment maintenance; Complete required GMP training; follow GMP during
clinical manufacturing; Attend and participate in regularly scheduled
meetings; Collect and compile data and records in laboratory
notebook; ensure laboratory notebooks are consistently updated
audited and well maintained.
Scientist Ii/Iii/Iv Or Engineer I/Ii, Purification Process Development
Opportunity and Summary of Position:
Scientist II/III/IV or Engineer I/II Purification Process Development, is a position that will support the development and characterization of robust purification processes for biosimilar monoclonal antibodies and fusion proteins including chromatography and multiple types of filtration processes. This position will support the Oncobiologics pipeline which spans early and late phase process development needs. Scientist I/II/III or Engineer I/II, Purification Process Development, will be responsible for contributing to the planning, execution, analysis, and reporting of experiments related to the development of manufacturing processes for biosimilars. Scientist II/III/IV or Engineer I/II, Purification Process Development, will report to Associate Director, Purification Development.
Develop scalable filtration processes including methods for depth filtration, tangential flow filtration, and viral clearance. This should include working knowledge of filter capacity screening and evaluation.
Evaluate chromatography resins and membrane adsorbers (e.g. Protein A, ion exchange, mixed mode, hydrophobic interaction) to be used in purification processes and process models.
Perform process characterization studies for purification unit operations, including scale-down model studies, range studies, and resin lifetime studies.
Perform viral clearance studies at an offsite contract laboratory.
Develop scalable chromatography methods that maximize efficiency of operations in manufacturing.
Perform small scale purification in support of cell line and cell culture development organizations.
Maintain a current electronic laboratory notebook with scientific rigor to meet project needs for process development.
Author and review documentation, including but not limited to, technical transfer protocols and development reports.
Present data in team meetings as required.
Provide process support to functional areas as needed.
Execute process development enabling analytics required to make development decisions rapidly.
Remain current with respect to chromatography techniques and equipment.
Operate safely and according to company environmental requirements.
Maintain current lab environment (e.g. buffer/solution preparation, raw material ordering, equipment maintenance and repair, hazardous waste disposal).
Qualifications & Experience:
The company is seeking an individual with the following qualifications:
B.S/M.S/Ph.D Biochemistry, Chemistry, Chemical Engineering or equivalent field.
Minimum 2+ years of experience in absence of graduate degree. Position will be commensurate with experience.
Experience using GE Healthcare AKTA instruments and Unicorn software.
Demonstrated ability in all modes of chromatography including column packing and buffer/solution preparation.
Experience in developing chromatography and filtration scale-down models for use in protocol driven process characterization and validation activities is desirable.
Experience in filtration including general operation as well as capacity determination.
Must be familiar with GMP guidance(s) and support clinical and commercial manufacturing with appropriately developed process.
Experience in viral clearance studies is desirable.
Experience with HPLC/UPLC; experience with electrophoretic, ELISA, and associated equipment is desirable.
Excellent communication skills in English, both verbal and written, and the ability to interface effectively with analytical, process, and business development is required.
Good conceptual, analytical, problem solving, and organizational skills – must be detail-oriented, well organized, and able to work independently and in teams.
A "hands-on" energetic individual who enjoys challenges, a quick pace, and is capable and dedicated to getting the job done.
An assertive, take-charge, scientist or engineer with a strong results orientation, positive "can do" attitude, and a sense of urgency to get things done.
The ability to listen to, learn about, and build upon organizational best practices and successes.
A competent, fast learning individual with the ability to multitask and adapt to change.
A mature thinking and acting scientist or engineer with good common sense and judgment.
Location: Cranbury, NJ
Associate Scientist 1, Purification & Chemical Process Development
The Purification & Chemical Process Development team is seeking an associate scientist with experience in in sample preparation for analytical methods. The position requires the ability to follow standard operating procedures, the ability to calculate dilution factors and perform small scale extractions and work with laboratory equipment for evaporation and filtration. The ideal candidate should be experienced in sample preparation, including the use of volumetric pipettors and analytical balances, have an understanding of fundamental chemistry concepts, chemical safety, and familiarity with analytical equipment such as GC-FID and HPLC. One of the goals of the Purification & Chemical Process Development team is to build quality, safety, and cost-efficiency into processes as they are developed and analytical data quality is important to these goals. The position requires laboratory experience with a safety first approach to all aspects of the work environment and interactions with several disciplines, including Process Development, Process Analytical Chemistry, and Environmental Health & Safety. Amyris is a renewable products company devoted to creating a more sustainable world. Amyris makes sustainable products by applying a unique science platform that enables us to create No Compromise® renewable chemicals.
Responsibility for individual as well as co-worker safety and maintaining safety as the highest priority by supporting and reinforcing procedures and policies.
Sample preparation per SOPs and data capture using ChemStation and Chromeleon software.
Transfer of data into Microsoft Excel spreadsheets and data analysis when required.
Prioritize samples from multiple sample streams and communicate sample status to team.
Maintain and update spreadsheets for sample streams.
Use laboratory equipment for solvent extraction, evaporation and filtrations.
B.A., or B.S. Degree in Chemistry, or related field.
1+ year of laboratory experience.
Established experience in chemical laboratory and chemical safety.
Established experience with sample preparation equipment, including PPE, pipettors, balances and common chemical solvents.
Experience with Microsoft Excel.
Experience with analytical data.
Experience with GC-FID and HPLC a plus.
Experience with ChemStation and Chromeleon a plus.
Team oriented, with good communication skills.
Embrace Amyris Core Values.
Amyris, a leader in industrial synthetic biology, uses its innovative bioscience solutions to achieve renewable products by converting plant sugars into hydrocarbon molecules. Amyris' molecules are used in wide range of specialty & performance chemicals, flavors & fragrances and in applications ranging from cosmetics to biofuels. Learn more at www.amyris.com.
As a VEVRAA Federal Contractor, Amyris is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, sex, color, religion, sexual orientation, gender identity, national origin, disability status, protected veteran status, or any other characteristic protected by law. Amyris complies with applicable state and local laws governing nondiscrimination in employment.
If you are a recruiter or placement agency, please do not submit resumes to any person or email address at Amyris, Inc. prior to having a signed agreement. Amyris is not liable for and will not pay placement fees for candidates submitted by any agency other than its approved recruitment partners. Furthermore, any resumes sent to us without an agreement in place will be considered your company's gift to Amyris and may be forwarded to our recruiters for their attention.
For a full list of our current openings, please visit our website .
Scientist Iii, Protein Purification
Job ID :
US - California - Carlsbad
When you're part of the team at Thermo Fisher Scientific, you'll do important work, like helping customers in finding cures for cancer, protecting the environment or making sure our food is safe. Your work will have real-world impact, and you'll be supported in achieving your career goals.
How will you make an impact?
Work in a team based environment to perform all tasks related to the production and qualification of purified proteins for use in research and commercial products for use in the life sciences industry.
What will you do?
Responsible for manufacturing product(s) in a lab setting following standard operating procedures. Will utilize basic laboratory techniques, calculations, materials measurement, operation of laboratory equipment and record keeping necessary to manufacture products.
Will perform column purification/ chromatography, buffer preparation, SDS-Page Analysis, Western Blotting, and other protein characterization techniques.
Responsible for Batch Data Records, notebooks, customer reports and work order documents.
Utilize specialized technical knowledge and skills to make detailed observations and analyze data to ensure within operating parameters. Advise manager of factors that may affect quality of product. Suggest and execute on options/ideas for corrective actions.
Maintain equipment, product inventories and related records as assigned. Note variances on manufacturing documents; audit and evaluate process documents and propose revisions. Complete, distribute and file records as required in accordance with Document Control Practices.
Identify potential issues in the production process; report findings to team management and lead troubleshooting and resolution process.
Write technical documents which include standard operating procedures and manufacturing batch records.
Required to lead process improvement projects, or product transfer projects, to resolve a technical issue, reduce process scrap or improve productivity.
Will require some leadership tasks, including but not limited to training new operators and partnering with support functions to facilitate execution of production schedules.
How will you get here?
- Must have a Bachelors degree in Biology, Chemistry, Biochemistry, or other related discipline with 7+ years relevant protein purification experience. Or Masters degree in Biology, Chemistry, Biochemistry or other related discipline with 5 years relevant protein purification experience. PhD is a plus.
- Requires a minimum of 5 years relevant experience demonstrating laboratory techniques in a manufacturing environment or research laboratory.
Knowledge, Skills, Abilities
Demonstrated proficiency in the use of scientific laboratory techniques, equipment and materials required. Experience in the use of basic laboratory techniques, including buffer preparation, column purification/ chromatography, SDS-Page Analysis, Western Blotting, and other protein characterization techniques.
Expert level operation of GE AKTA FPLC protein chromatography equipment and ability to write chromatography programs in Unicorn software. Or equivalent system.
Experience with different modes of chromatography such as: affinity, ion-exchange, size exclusion, hydrophobic interaction. In depth understanding of protein/resin interactions.
Lifting up to 20 lbs will be required on a frequent basis.
May be required to stand for long periods of time while performing duties.
Must be flexible to work varying schedules and hours as needed.
Must be able to work safely with chemicals and hazardous materials.
Must be able to work in +4C Cold-Room.
Preferred Knowledge, Skills, Abilities (Leadership Behaviors):
Consistent, dependable and accurate in carrying out responsibilities
Displays positive attitude toward job and others
Follows and provides direction accurately and efficiently
Excellent documentation and communication skills
Demonstrated ability to carry out scientific procedures and make recommendations for improvement required.
Good problem solving skills necessary.
Working knowledge of manufacturing and quality system related computer software preferred. E1, Agile, TrackWise are a plus.
Intermediate Excel skills
This position has not been approved for Relocation Assistance.
At Thermo Fisher Scientific, each one of our 65,000 extraordinary minds has a unique story to tell. Join us and contribute to our singular mission—enabling our customers to make the world healthier, cleaner and safer.
Apply today! http://jobs.thermofisher.com
Thermo Fisher Scientific is an EEO/Affirmative Action Employer and does not discriminate on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability or any other legally protected status.
Purification Development Co-Op, Fall 2018
Known for its scientific and operational excellence, Regeneron is a leading science-based biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. Regeneron commercializes medicines for eye diseases, high LDL-cholesterol, atopic dermatitis and a rare inflammatory condition and has product candidates in development in other areas of high unmet medical need, including rheumatoid arthritis, asthma, pain, cancer and infectious diseases.
These positions are in Purification Development within Preclinical Manufacturing and Process Development in Tarrytown, NY. These positions are for Fall 2018 (full time, from August to December 2018). Each opening is described below.
Position 1: The student will work upon a specific development project that will be attempting to improve our platform process for the purification of monoclonal antibodies from mammalian cell culture. The project will focus upon the initial downstream process steps of cell removal and mAb capture.
Position 2: The student will support daily activities of designing clinical and commercial purification processes for promising antibody treatments in addition to supporting technology development.
Assist in reagent molecule purification and gain experience in operation of membrane unit operations and AKTA liquid chromatography handling systems.
Assist with clinical and commercial purification process development and gain experience in membrane systems, antibody fundamentals, risk management, among others.
Assist with purification department raw material inventory management and stocking.
Independent research project to support technology development.
Assist in daily lab operation to ensure proper maintenance of equipment and availability of buffers.
Work under mentorship of a process development engineer.
Start building your skills at Regeneron.
Must be an undergraduate student, prefer rising junior or above
Must be pursuing a degree in Chemical Engineering, Bioengineering, Biomedical Engineering, Biology, or related fields with an interest in the biopharmaceutical industry
Academic research or industry experience in a laboratory setting for >0.5yrs, pipetting, buffer preparation, good attention to detail, and the ability to balance multiple concurrent projects
General Intern/Co-op Program Information:
Must be enrolled in, or accepted to, an academic program pursuing a Bachelor's, Master's, PhD or PharmD
Program is full-time (~40 hrs/wk) and is paid
Prefer demonstrated leadership in areas such as campus activities, clubs, sports or the community
Minimum GPA of 3.0
You will work with a specific manager on a project(s)
Enjoy weekly 1 hour Intern Program events: learn about other areas of the company from VPs and other employees, soft skills workshops, networking, volunteering, and more!
Present to your team on your summer project
Transportation and Housing:
A free shuttle is offered from the North White Plains or Tarrytown train stations to the Tarrytown campus
Get to know other incoming Interns on our closed LinkedIn page when you accept an offer
This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry. Apply today and learn more about Regeneron's unwavering commitment to combining good science & good business.
To all agencies: Please, no phone calls or emails to any employee of Regeneron about this opening. All resumes submitted by search firms/employment agencies to any employee at Regeneron via-email, the internet or in any form and/or method will be deemed the sole property of Regeneron, unless such search firms/employment agencies were engaged by Regeneron for this position and a valid agreement with Regeneron is in place. In the event a candidate who was submitted outside of the Regeneron agency engagement process is hired, no fee or payment of any kind will be paid.
Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.
Manufacturing Associate III - Protein Purification
MacroGenics is a leader in the discovery and development of innovative medicines that utilize our next generation antibody-based technologies. Our team of 300+ dedicated individuals is advancing a pipeline of product candidates to treat patients with cancer as well as various autoimmune disorders and infectious diseases. Our products and platforms have attracted multiple partnerships with leading pharmaceutical companies around the globe.
The Company considers its employees to be its most valuable asset and we are committed to providing opportunities for individuals to learn and grow as a means to further their professional development. MacroGenics' corporate culture promotes an atmosphere of innovation, open communication and teamwork where employees can see firsthand how they contribute to the success of the organization.
Summary of Position
The Manufacturing Associate III participates in the manufacturing of biopharmaceutical drug product to support MacroGenics' multiple clinical programs in the Protein Purification area. This position will work in the manufacturing suite under GMP (Good Manufacturing Practices) to ensure that materials manufactured meet required specifications and regulatory requirements.
Responsibilities and Job Duties
Conduct purification operations including filtration, chromatography, titrations, column packing, and order and account for consumption of raw materials and components. Operate bioprocess equipment under strict adherence to cGMP, OSHA and required policies and regulations.
Prepare and maintain reports and other documentation as applicable to the scope of operations in the manufacturing facility.
Collaborate with the Quality Assurance group to fulfill quality management goals and ensure the highest quality manufacturing processes.
Plan for raw material requirements by maintaining appropriate inventory of chemicals/consumables and ordering them as needed.
Coordinate sample testing and room release with QC.
Assist with technical issues and problems and identify solutions and improvements.
Responsible for scale-up and basic trouble-shooting of technical issues and other problems encountered within the manufacturing process.
Monitor, maintain and calibrate laboratory equipment as needed.
Monitor and audit work processes to ensure compliance and completion of targets.
Prepare and revise batch records and SOPs, as well as drafting of technical reports.
Write deviation/incident reports as needed.
Identify areas for improvement in manufacturing efficiencies and compliance.
Assist with technology transfer from Process Development to manufacturing environment.
Prepare (wipe down) equipment for use in cleanroom environment. Maintain working inventories of supplies within the production area.
Perform buffer preparation, chromatography, and filtration processing steps.
Organize projects and data using Excel, Word, Powerpoint and a document control system.
Maintain a clean and safe plant environment.
Participate in training of junior team members.
Education & Experience
- High School Diploma or equivalent and a minimum of seven years of related biopharmaceutical manufacturing experience in FDA regulated, controlled production environment
Associate's degree in a related discipline and a minimum of three year of related biopharmaceutical manufacturing experience in FDA regulated, controlled production environment
Prior experience following GMP rules and procedures
Knowledge, Skills and Abilities
Knowledge of protein purification techniques
Ability to write and revise technical documents
Critical thinker who can analyze date and respond quickly to manage manufacturing projects
Ability to mentor and train others
Ability to manage multiple projects
Strong organizational skills
Engaged and committed team professional who is committed to generating quality products
Professional work ethic driven by manufacturing time-lines
Passion for continuous improvement
Independent thinker and self-learner
Manual dexterity and attention to detail are required
Technical accuracy and ability to perform mathematical calculations
Strong interpersonal skills and the ability to work effectively and efficiently in a team environment
Ability to work flexible hours, including possible overtime and weekends
Ability to lift up to 30 lbs.
MacroGenics is proud to be an equal opportunity employer. Employment selection and related decisions are made without regard to race, color, national origin, sex, gender identity, sexual orientation, religion, age, disability, protected veteran status, or any other characteristic protected by federal, state or local law. We are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the employment process, please email firstname.lastname@example.org or call (301) 354-3566 and/or 711 for TTD/TTY service. Equal Opportunity Employer/Veterans/Disabled
For more information about our commitment to equal employment opportunity, please click here.
Protein Purification Technician I
The Protein Purification Technician I performs assigned manufacturing and process development duties in a ISO 13485 environment.
Job performance will involve a variety of activities including:
Execute development and production scale purification protocols as directed.
Work with standard scientific equipment as described in relevant procedures; AKTA Purifier and AKTA Pilot, UV spectrophotometer, balances, chromatography columns, SDS-PAGE, autoclaves, pH meter, refrigerators, freezers, biohazard safety cabinets.
Record results in laboratory notebooks; required to have meticulous organization and record keeping skills.
Prepare buffers and solutions.
Communicate as a team member with other functional groups, via face to face, email and written reports.
- Bachelor's degree from four year college or university and/or combination of experience and training.
- 1-2 years related life sciences experience or equivalent combination of education and experience.
Drive and Determination.
Ability to participate with others as a member of the team to ensure that demanding and difficult projects are handled smoothly and cooperatively to enhance success of project and maintain strong relationships within all parts of company.
Strong communication skills.
Ability to work flexible hours to complete tasks as required.
We are an Equal Opportunity Employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity, status as a veteran, and basis of disability or any other federal, state or local protected class.
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